IGFBP-4 Protein, Human (237a.a, HEK293, His)

IGFBP-4 protein is an important IGFBP member that prolongs the half-life of insulin-like growth factor (IGF) and modulates its effects on cell cultures by altering the kinetics of interaction with cell surface receptors. It can inhibit or stimulate IGF-induced growth responses, showing specificity for IGF2 but not IGF1. IGFBP-4 Protein, Human (237a.a, HEK293, His) is the recombinant human-derived IGFBP-4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IGFBP-4 Protein, Human (237a.a, HEK293, His) is 237 a.a., with molecular weight of 30-35 kDa.

IGFBP-4 Protein, a member of the insulin-like growth factor-binding proteins (IGFBPs), plays a vital role in extending the half-life of insulin-like growth factors (IGFs) and modulating their effects on cell culture. With the ability to either inhibit or stimulate IGF-induced growth-promoting effects, IGFBP-4 achieves this regulatory function by altering the interaction dynamics between IGFs and their respective cell surface receptors. Notably, IGFBP-4 exhibits a preferential binding affinity for IGF2 over IGF1, highlighting its specificity in modulating the interactions between different IGF isoforms and their receptors. This differential binding capacity underscores the intricate regulatory role of IGFBP-4 in fine-tuning the cellular responses to IGFs, emphasizing its significance in the complex network that governs growth-related signaling pathways.

Human

HEK293

C-6*His

P22692 (D22-E258)

3487  [NCBI]

DEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE

30-35 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.