IGFBP4 - insulin like growth factor binding protein 4 Gene

Also Known as BP-4; IBP4; IGFBP-4; HT29-IGFBP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3487

About IGFBP4

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,443,450-40,457,725 (from NCBI)

This gene has 1 transcript (splice variant), 185 orthologues and 5 paralogues. Ubiquitous expression in liver (RPKM 316.3), ovary (RPKM 298.9) and 21 other tissues.

Summary

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

IGFBP4 Products (1)

mRNA	Protein	Name
NM_001552.3	NP_001543.2	insulin-like growth factor-binding protein 4 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15642270	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGFBP4 Protein Structure

IGFBP

Thyroglobulin_1

0
100
200
258 a.a.

Protein Preferred Names	Protein Names
insulin-like growth factor-binding protein 4	IBP-4

IGFBP4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IGFBP4	P22692	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	IGFBP4	P22692	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	IGFBP4	P22692	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	IGFBP4	P22692	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	IGFBP4	P22692	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	IGFBP4	P22692	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	IGFBP4	P22692	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	IGFBP4	P22692	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	IGFBP4	P22692	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	IGFBP4	P22692	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	IGFBP4	P22692	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	IGFBP4	P22692	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	IGFBP4	P22692	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	IGFBP4	P22692	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	IGFBP4	P22692	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	IGFBP4	P22692	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	IGFBP4	P22692	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	IGFBP4	P22692	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	IGFBP4	P22692	TOR1A	Homo sapiens	O14656	Validated Y2H	32814053
Intra	IGFBP4	P22692	TOR1A	Homo sapiens	O14656	Y2H Array	32814053
Intra	IGFBP4	P22692	TOR1A	Homo sapiens	O14656	Y2H Pooling	32814053
Intra	IGFBP4	P22692	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	IGFBP4	P22692	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	IGFBP4	P22692	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	IGFBP4	P22692	IGF1	Homo sapiens	P05019	GMS	16924115
Intra	IGFBP4	P22692	IGF1	Homo sapiens	P05019	X-Ray Diffraction	15642270
Intra	IGFBP4	P22692	IGF1	Homo sapiens	P05019	ITC	16924115
Intra	IGFBP4	P22692	IGF1	Homo sapiens	P05019	X-Ray Diffraction	16924115
Intra	IGFBP4	P22692	ATXN3	Homo sapiens	P54252	Y2H Array	32814053
Intra	IGFBP4	P22692	ATXN3	Homo sapiens	P54252	Validated Y2H	32814053
Intra	IGFBP4	P22692	ATXN3	Homo sapiens	P54252	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IGFBP4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7369	IGFBP-4 Protein, Human (HEK293, His)	P22692-1 (D22-E258)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Insulin-Like Growth Factor I	Insulin-Like Growth Factor I Deficiency IGF1 DEFICIENCY Insulin-Like Growth Factor I, Resistance To Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency Growth Delay Due To Insulin-Like Growth Factor I Resistance IGF1RES Igf-I Resistance Somatomedin, End-Organ Insensitivity To Somatomedin-C Somatomedin-C, Resistance To Growth Retardation With Sensorineural Deafness And Mental Retardation Insulin-Like Growth Factor 1 Resistance To Igf-1 Resistance Somatomedin End-Organ Insensitivity To Somatomedin-C Resistance To Growth Restriction With Sensorineural Deafness And Intellectual Disability Growth Delay-Deafness-Intellectual Disability Syndrome Growth Delay-Hearing Loss-Intellectual Disability Syndrome Igf-1 Deficiency Primary Insulin-Like Growth Factor Deficiency Resistance To Igf-1 Insulin-Like Growth Factor 1 Resistance End-Organ Insensitivity To Somatomedin Igf1 Resistance Resistance To Insulin-Like Growth Factor I Resistance To Somatomedin-C Insulin-Like Growth Factor 1, Resistance To
Renal Osteodystrophy	Renal Rickets Chronic Kidney Disease-Mineral And Bone Disorder
Polycystic Ovary Syndrome	Polycystic Ovarian Syndrome Pcos Polycystic Ovarian Disease Polycystic Ovaries Stein-Leventhal Syndrome Multicystic Ovaries Polycystic Ovary Sclerocystic Ovaries Sclerocystic Ovary Syndrome Stein-Leventhal Synd. Cystic Disease Of Ovaries Cystic Disease Of Ovary Pco Pcod Sclerocystic Ovarian Degeneration Polycystic Ovary Syndrome, Susceptibility To Pcos - [Polycystic Ovary Syndrome] Polycystic Ovary Nos Pco - [Polycystic Ovary]
Sotos Syndrome	Cerebral Gigantism SOTOS Chromosome 5q35 Deletion Syndrome Sotos Syndrome 1, Formerly Sotos1, Formerly Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development Sotos Sequence Sotos' Syndrome Sotos1 Sotos Syndrome 1
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06627	IGFBP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174649	Human IGFBP4 mRNA		/	Unkown
HY-RS19779	Igfbp4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26276	Igfbp4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IGFBP4	VGNC	VGNC:30086
Felis catus	IGFBP4	VGNC	VGNC:99091
Mus musculus	IGFBP4	MGD	MGI:96439
Canis familiaris	IGFBP4	VGNC	VGNC:41905
Macaca mulatta	IGFBP4	VGNC	VGNC:73577
Rattus norvegicus	IGFBP4	RGD	RGD:2875
Others	IGFBP4	NCBI