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2381320-35-8

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125878
    PROTAC SGK3 degrader-1
    2 Publications Verification

    SGK3-PROTAC1

    		 PROTACs SGK Cancer
    PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on von Hippel-Lindau ligand. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate) .
    PROTAC SGK3 degrader-1

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