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2682112-10-1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W584517
    Thalidomide-5-O-CH2-COO(t-Bu)

    		Ligands for E3 Ligase Cancer
    Thalidomide-5-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
    Thalidomide-5-O-CH2-COO(t-Bu)

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