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AChE/BChE-IN-12

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-149211
    AChE/BChE-IN-12

    		Cholinesterase (ChE) Beta-secretase Amyloid-β Neurological Disease
    AChE/BChE-IN-12 (compound 10b), a 3,5-dimethoxy analogue, is a potent AChE, BChE, and β-secretase-1 (BACE-1) inhibitor, with IC50 values of 2.57, 3.26, and 10.65 μM, respectively. AChE/BChE-IN-12 crosses the blood-brain barrier via passive diffusion and inhibits the self-aggregation of amyloid-β monomers. AChE/BChE-IN-12 can be used for Alzheimer’s disease (AD) research .
    <em>AChE/BChE-IN-12</em>

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