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FCGR3A

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  • HY-P78879
    Fc gamma RIIIA/CD16a Protein, Cynomolgus (Biotinylated, HEK293, His-Avi)

    Low affinity immunoglobulin gamma Fc region receptor III-A; FcRIIIa; FcR-10; CD16a; FCGR3A; IGFR3

    		 Cynomolgus HEK293
    FcγRIIIA/CD16a Protein, a receptor for IgG, optimally activates upon clustered antigen-IgG complex binding, inducing antibody-dependent cellular cytotoxicity (ADCC). It mediates IgG effector functions on natural killer cells, limiting viral load. FcγRIIIA generates memory-like adaptive NK cells, crucial for NK cell activation. As a Fc-binding subunit, it forms signaling complexes with CD247 and/or FCER1G, initiating intracellular pathways. FcγRIIIA costimulates NK cells, triggering lysis independently of IgG binding. It plays a role in antitumor activities, induces TNFA-dependent ADCC, interacts with CD2 for NK cell activation, and interacts with S100A4, inhibiting FCGR3A phosphorylation. Fc gamma RIIIA/CD16a Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived Fc gamma RIIIA/CD16a protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of Fc gamma RIIIA/CD16a Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is 192 a.a., with molecular weight of 36-45 kDa.
  • HY-P7806
    Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His)

    rCynFc-gamma receptor 3A/CD16a, His; Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; CD16a Antigen; Fc-Gamma RIII-Alpha; Fc-Gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc Receptor III-2; CD16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3

    		 Cynomolgus HEK293
    FCGR3A is a receptor for the Fc portion of immunoglobulin G that enhances antibody-dependent cell-mediated cytotoxicity and antibody-dependent viral infection. FCGR3A is also a potential immune oncogenic molecule and is related to the level of tumor immune infiltration. FCGR3A is often used as a biomarker with prognostic value in prostate cancer (PCa). Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Fc gamma RIIIA/CD16a protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His) is 186 a.a., with molecular weight of 30-40 kDa.

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