2. Recombinant Proteins
  3. Immune Checkpoint Proteins CD Antigens Fc Receptors
  4. Inhibitory Checkpoint Molecules T Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins Fc-gamma Receptor
  5. FcγRIIIA/CD16a CD300a Fc gamma RIII/CD16
  6. Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His)

Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His)

Cat. No.: HY-P7806
Handling Instructions

FCGR3A is a receptor for the Fc portion of immunoglobulin G that enhances antibody-dependent cell-mediated cytotoxicity and antibody-dependent viral infection. FCGR3A is also a potential immune oncogenic molecule and is related to the level of tumor immune infiltration. FCGR3A is often used as a biomarker with prognostic value in prostate cancer (PCa). Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Fc gamma RIIIA/CD16a protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His) is 186 a.a., with molecular weight of 30-40 kDa.

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Description

FCGR3A is a receptor for the Fc portion of immunoglobulin G that enhances antibody-dependent cell-mediated cytotoxicity and antibody-dependent viral infection. FCGR3A is also a potential immune oncogenic molecule and is related to the level of tumor immune infiltration. FCGR3A is often used as a biomarker with prognostic value in prostate cancer (PCa). Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Fc gamma RIIIA/CD16a protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His) is 186 a.a., with molecular weight of 30-40 kDa.
Background

FCGR3A 是一种免疫球蛋白 G Fc 部分的受体，是自然杀伤 (NK) 细胞上表达为通过跨膜肽锚定的完整膜糖蛋白。而 FCGR3B 在多形核中性粒细胞 (PMN) 上表达，其中受体通过磷脂酰肌醇 (PI) 连接锚定。FCGR3A 可增强抗体依赖性细胞介导的细胞毒性和抗体依赖性病毒感染。公开数据库的差异分析结果表明 FCGR3A 在泛癌中普遍高表达，其表达量被证实与全身性癌中多种免疫细胞浸润、多种免疫检查点基因和 DNA 错配修复基因的表达有关。FCGR3A 和 DNA 甲基化水平之间存在负相关性。FCGR3A 和 HAVCR2 在 PCa 中高表达，并且与 PCa患者的无 BCR 生存期相关。因此，FCGR3A 是一种具有潜在前列腺癌 (PCa) 预后价值的生物标志物。FCGR3A 还可能是一种免疫致癌分子，与肿瘤免疫浸润水平相关并影响药物敏感性。此外，研究发现 FCGR3A 基因重复与 HIV-1 获得相关，FCGR3A 的等位基因变异在婴儿 HIV-1 感染中发挥作用，控制 HIV-1 感染的易感性。
Species

Cynomolgus
Source

HEK293
Tag

C-6*His
Accession

A0A140HDP8 (E21-G206)
Gene ID

102140945  [NCBI]
Molecular Construction
N-term
CD16a (E21-G206)
Accession # A0A140HDP8
6*His
C-term
Synonyms
rCynFc-gamma receptor 3A/CD16a, His; Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; CD16a Antigen; Fc-Gamma RIII-Alpha; Fc-Gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc Receptor III-2; CD16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3
AA Sequence

EDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTRWFHNESLISSQTSSYFIAAARVNNSGEYRCQTSLSTLSDPVQLEVHIGWLLLQAPRWVFKEEESIHLRCHSWKNTLLHKVTYLQNGKGRKYFHQNSDFYIPKATLKDSGSYFCRGLIGSKNVSSETVNITITQDLAVSSISSFFPPG

Molecular Weight

30-40 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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