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HAVCR2

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  • HY-P72447
    TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, His)

    Hepatitis A virus cellular receptor 2 homolog; T cell immunoglobulin and mucin domain3; HAVCR2; CD366; TIM3

    		 Cynomolgus HEK293
    The TIM-3/HAVCR2 protein is a cell surface receptor that regulates immune responses by inhibiting macrophage activation and suppressing Th1-mediated autoimmunity. TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with N-8*His labeled tag. The total length of TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, His) is 180 a.a., with molecular weight of 26-30 kDa.
  • HY-P74509
    TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, Fc)

    Hepatitis A virus cellular receptor 2; HAVCR2; CD366; TIM3

    		 Cynomolgus HEK293
    TREM-2 Protein binds to DAP10 activates the PI3K signaling pathway. TREM2 signaling leads to downregulated transcription of genes that promote inflammation (Tnf, Il1b, and Nos2), as well as release of cytokines that prevent activation of anti-tumor CD8+ T cells. In addition, it signaling can antagonize TLR expression and signaling, resulting in reduced production of inflammatory cytokines by cultured mouse macrophages. The neuroprotective effects of TREM2 involve not only production of anti-inflammatory cytokines, but also clearance of abnormal proteins and phagocytosis of apoptotic neurons. TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, Fc) is 201 a.a., with molecular weight of ~60.5 & 35.8 kDa, respectively.

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