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HG-7-85-01

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15814
    HG-7-85-01

    		Bcr-Abl PDGFR c-Kit Src JAK Apoptosis Cancer
    HG-7-85-01 is a type II ATP competitive inhibitor of wild-type and gatekeeper mutations forms of Bcr-Abl, PDGFRα, Kit, and Src kinases. HG-7-85-01 inhibits T315I mutant Bcr-Abl kinase, KDR and RET with IC50s of 3 nM, 20 nM and 30 nM, and is only weak or no inhibition of other kinases (IC50>2 μM). HG-7-85-01 inhibits the cell proliferation, which is mediated by the induction of apoptosis, and inhibition of cell-cycle progression .
    <em>HG-7-85-01</em>
  • HY-131178
    HG-7-85-01-NH2

    		PROTACs Others
    HG-7-85-01-NH2 is the ligand of SNIPER(ABL)-033. SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 value of 0.3 μM .
    <em>HG-7-85-01</em>-NH2
  • HY-111855
    HG-7-85-01-Decyclopropane

    PROTAC ABL binding moiety 3

    		 Ligands for Target Protein for PROTAC Cancer
    HG-7-85-01-Decyclopropane, the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
    <em>HG-7-85-01</em>-Decyclopropane
  • HY-111862
    SNIPER(ABL)-044

    		SNIPERs Bcr-Abl Cancer
    SNIPER(ABL)-044, conjugating HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM .
    SNIPER(ABL)-044
  • HY-111863
    SNIPER(ABL)-047

    		SNIPERs Bcr-Abl Cancer
    SNIPER(ABL)-047, conjugating HG-7-85-01 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 2 μM .
    SNIPER(ABL)-047
  • HY-111871
    SNIPER(ABL)-033

    		SNIPERs Bcr-Abl Cancer
    SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 0.3 μM .
    SNIPER(ABL)-033

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