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IL23A

" in MedChemExpress (MCE) Product Catalog:
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  • HY-P74874
    Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His)

    IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF

    		 Mouse;Human HEK293
    IL-23, collaborating with IL12B, constitutes the pro-inflammatory cytokine IL-23, crucial in innate and adaptive immunity. Released by antigen-presenting cells like dendritic cells or macrophages, IL-23 binds to IL12RB1 and IL23R, activating JAK2 and TYK2. This cascade phosphorylates STAT3 and STAT4, activating pathways like p38 MAPK or NF-kappa-B, inducing pro-inflammatory cytokines. IL-23 contributes to intracellular bacterial clearance and supports the expansion of T-helper 17 cells, including IL-17 producers. The disulfide-linked IL-23 interacts with IL12B and IL23R, recruiting IL12RB1. Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His) is a recombinant protein dimer complex containing mouse, human-derived Human IL-23 alpha & Mouse IL-12 beta Heterodimer protein, expressed by HEK293, with C-His, C-6*His labeled tag. Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His), has molecular weight of ~23.18 & 40-50 kDa, respectively.
  • HY-P78152
    IL-23 alpha Protein, Mouse (Biotinylated, HEK293, His-Avi)

    Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19; IL23p19; IL23A; P19; SGRF

    		 Mouse HEK293
    IL-23 alpha, a crucial component, combines with IL12B to create the IL-23 interleukin, a heterodimeric cytokine pivotal in innate and adaptive immunity. Operating in peripheral tissues, IL-23, along with IL-17, responds acutely to infections. It binds to IL12RB1 and IL23R, activating Jak-Stat signaling, preferentially stimulating memory T-cells, and inducing pro-inflammatory cytokines. Released by antigen-presenting cells, IL-23 plays a role in autoimmune inflammation, contributing to autoimmune diseases and tumorigenesis, and supports the expansion of T-helper 17 cells. IL-23 alpha Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived IL-23 alpha protein, expressed by HEK293, with C-His, C-Avi labeled tag. The total length of IL-23 alpha Protein, Mouse (Biotinylated, HEK293, His-Avi) is 175 a.a., with molecular weight of 23-28 kDa.
  • HY-P74814
    IL-23 alpha (175a.a) & IL-12 beta (313a.a) Heterodimer Protein, Mouse (HEK293, His)

    IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF

    		 Mouse HEK293
    IL-23 alpha, a crucial component, combines with IL12B to create the IL-23 interleukin, a heterodimeric cytokine pivotal in innate and adaptive immunity. Operating in peripheral tissues, IL-23, along with IL-17, responds acutely to infections. It binds to IL12RB1 and IL23R, activating Jak-Stat signaling, preferentially stimulating memory T-cells, and inducing pro-inflammatory cytokines. Released by antigen-presenting cells, IL-23 plays a role in autoimmune inflammation, contributing to autoimmune diseases and tumorigenesis, and supports the expansion of T-helper 17 cells. IL-23 alpha (175a.a) & IL-12 beta (313a.a) Heterodimer Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived IL-23 alpha, expressed by HEK293, with C-His labeled tag. IL-23 alpha (175a.a) & IL-12 beta (313a.a) Heterodimer Protein, Mouse (HEK293, His), has molecular weight of ~47 & 45 & 26 kDa, respectively.
  • HY-P72771
    Human IL-23A & Mouse IL-12B Heterodimer Protein (HEK293, His)

    SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2

    		 Mouse;Human HEK293
    IL-23, collaborating with IL12B, constitutes the pro-inflammatory cytokine IL-23, crucial in innate and adaptive immunity. Released by antigen-presenting cells like dendritic cells or macrophages, IL-23 binds to IL12RB1 and IL23R, activating JAK2 and TYK2. This cascade phosphorylates STAT3 and STAT4, activating pathways like p38 MAPK or NF-kappa-B, inducing pro-inflammatory cytokines. IL-23 contributes to intracellular bacterial clearance and supports the expansion of T-helper 17 cells, including IL-17 producers. The disulfide-linked IL-23 interacts with IL12B and IL23R, recruiting IL12RB1. Human IL-23A & Mouse IL-12B Heterodimer Protein (HEK293, His) is a recombinant protein dimer complex containing mouse, human-derived Human IL-23A & Mouse IL-12B Heterodimer protein, expressed by HEK293, with C-6*His labeled tag. Human IL-23A & Mouse IL-12B Heterodimer Protein (HEK293, His), has molecular weight of 65-80 kDa.

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