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KLRC1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Compare Product Name Species Source
  • HY-P74690
    NKG2A Protein, Mouse (HEK293, His)

    NKG2-A/NKG2-B type II integral membrane protein; CD159a; KLRC1

    		 Mouse HEK293
    NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A Protein, Mouse (HEK293, His) is the recombinant mouse-derived NKG2A protein, expressed by HEK293 , with N-His labeled tag. The total length of NKG2A Protein, Mouse (HEK293, His) is 151 a.a., with molecular weight of 33-40 kDa.

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