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Results for "

LND

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134832
    Mito-LND
    1 Publications Verification

    Mito-Lonidamine

    		 Oxidative Phosphorylation Mitochondrial Metabolism Reactive Oxygen Species Autophagy Cancer
    Mito-LND (Mito-Lonidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS). Mito-LND inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species, and induces autophagic cell death in lung cancer cells .
    Mito-<em>LND</em>
  • HY-145767A
    SN-38-CO-DMEDA TFA

    		Others Others
    SN-38-CO-DMEDA TFA is the intermediate product for synthesizing antibody-conjugated drug LND1035 .
    SN-38-CO-DMEDA TFA
  • HY-45545
    Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

    		Others Others
    Fmoc-gly-gly-ph-gly-nh-ch2-o-ch2cooh can be used to synthesize the ADC Linker, LND1067 .
    Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
  • HY-155008
    PROTAC HK2 Degrader-1
    1 Publications Verification

    		 Hexokinase Cancer
    PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research .
    PROTAC HK2 Degrader-1
  • HY-144825
    Chol-CTPP

    		Apoptosis Reactive Oxygen Species Cancer
    Chol-CTPP is a ligand with dual targeting effect on blood-brain barrier (BBB) and glioma cells. Lip-CTPP can be gained by Chol-CTPP and another mitochondria targeting ligand (Chol-TPP). Lip-CTPP is a promising potential carrier to exert the anti-glioma effect of doxorubicin (DOX) and lonidamine (LND) collaboratively. Lip-CTPP elevates the inhibition rate of tumor cell proliferation, migration and invasion, promote apoptosis and necrosis, and interfere with mitochondrial function .
    Chol-CTPP

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