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MERTK

" in MedChemExpress (MCE) Product Catalog:
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  • HY-P73289
    Mer Protein, Mouse (sf9, His-GST)

    Mer; MERTK; STK kinase; Tyrosine-protein kinase Mer

    		 Mouse Sf9 insect cells
    Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1 or GAS6. Mer is critical in processes such as cell survival, migration, differentiation, and phagocytosis of apoptotic cells, and autophosphorylation occurs upon ligand binding. Mer Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Mer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Mer Protein, Mouse (sf9, His-GST) is 295 a.a., with molecular weight of ~58 kDa.
  • HY-P73820
    Mer Protein, Mouse (HEK293, Fc)

    Tyrosine-protein kinase Mer; MERTK; MER

    		 Mouse HEK293
    Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1 or GAS6. Mer is critical in processes such as cell survival, migration, differentiation, and phagocytosis of apoptotic cells, and autophosphorylation occurs upon ligand binding. Mer Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Mer protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Mer Protein, Mouse (HEK293, Fc) is 498 a.a., with molecular weight of ~130 kDa.
  • HY-P700446
    MERTK Protein, Mouse (HEK293, His)

    MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MERTK; MER; c-mer; MGC133349

    		 Mouse HEK293
    Mer Protein, a receptor tyrosine kinase, transduces signals by binding to ligands like LGALS3, TUB, TULP1, or GAS6. Crucial in processes such as cell survival, migration, differentiation, and apoptotic cell phagocytosis, Mer undergoes autophosphorylation upon ligand binding. This creates binding sites for downstream molecules, leading to interactions with GRB2 or PLCG2 and subsequent phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. Mer signaling influences macrophage clearance, platelet aggregation, cytoskeleton reorganization, and engulfment. Notably, in the retinal pigment epithelium, Mer regulates phagocytosis of rod outer segment fragments. Additionally, Mer inhibits the innate immune response triggered by Toll-like receptors (TLRs) by activating STAT1, inducing the production of suppressors of cytokine signaling SOCS1 and SOCS3. MERTK Protein, Mouse (HEK293, His) is the recombinant mouse-derived MERTK protein, expressed by HEK293, with C-10*His labeled tag. The total length of MERTK Protein, Mouse (HEK293, His) is 479 a.a., with molecular weight of 55.0 kDa.

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