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Results for "

TRADD

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

Cat. No. Compare Product Name Species Source
  • HY-P702570
    TRADD Protein, Human (GST)

    TNFR1 associated DEATH domain protein; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; TRADD; TRADD_HUMAN; Tumor necrosis factor receptor type 1 associated DEATH domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein

    		 Human E. coli
    TRADD protein acts as an adapter for TNFRSF1A/TNFR1, mediating its interaction with FADD. TRADD induces TNF-induced responses: apoptosis and NF-kappa-B activation. The nuclear form of TRADD functions as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A. Stimulation of TNFRSF1A forms plasma membrane-bound complex I, promoting cell survival. Subsequently, TRADD dissociates to form cytoplasmic complex II, inducing apoptosis. TRADD interacts with various proteins in these complexes, emphasizing its multifaceted role in cellular processes. TRADD Protein, Human (GST) is the recombinant human-derived TRADD protein, expressed by E. coli, with N-GST labeled tag. The total length of TRADD Protein, Human (GST) is 312 a.a., with molecular weight of 61.2 kDa.

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