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3PO

31 Cited Publications
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Based on 31 publication(s) in Google Scholar

3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+ and NADH. 3PO can be used for the research of cancer.

For research use only. We do not sell to patients.

  • Purity: 99.85%
  • CAS No.: 18550-98-6
  • Formula: C13H10N2O
  • Molecular Weight:210.23
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • 3PO Chemical Structure
    3PO Chemical Structure
  • Experimental Validation Results for 3PO
  • Experimental Validation Results for 3PO
  • Experimental Validation Results for 3PO
  • Experimental Validation Results for 3PO
  • Experimental Validation Results for 3PO
CAS No.: 18550-98-6
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  • 3PO Chemical Structure
    3PO Chemical Structure
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    3PO purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Dec;45(12):2579-2597. [Abstract]

    Customer Validation
     BMDMs isolated from C57BL/6J mice were incubated for 12 h with 10 μmol/L 3PO or vehicle in the presence of LPS (100 ng/mL) + IFN-γ (50 ng/mL). The supernatant levels of pro-inflammatory and anti-inflammatory cytokines measured by ELISA. n = 6 per group. The results showed that 3PO significantly reduced the supernatant levels of TNF-α and IL-6.

  • 1/16

    3PO purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Dec;45(12):2579-2597. [Abstract]

    Customer Validation
     BMDMs isolated from C57BL/6J mice were incubated for 12 h with 10 μmol/L 3PO or vehicle in the presence of LPS (100 ng/mL) + IFN-γ (50 ng/mL). The MFI of CD80 and CD86, and CD206 detected by flow cytometry. n = 3 per group. n = 6 per group. The results showed that 3PO significantly reduced the MFI of CD86, whereas it markedly increased the MFI of CD206.

  • 1/16

    3PO purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2024 Jan 6;24(1):12. [Abstract]

    Customer Validation
     RORα deletion promotes GC proliferation induced by 3PO and DHEA in vivo The expression levels of Ki-67 and PCNA were detected through immunohistochemistry stain and MOD method in subcutaneous tumor of mice. Original 200 and 400 magnification. Scale bar = 100 μm. N = 3. The RORα-KO-MFC cells treated with 3PO (25 µM; 48 h) or DHEA (250 µM) were injected into subcutaneous flank of mice until the tumor volume reached 100 to 300 mm3.

  • 1/16

    3PO purchased from MedChemExpress. Usage Cited in: Arch Toxicol. 2022 Nov;96(11):2913-2926. [Abstract]

    Customer Validation
     Cells were intervened with specific inhibitors Ritonavir, 3PO (24 μM), STF-31, NSC23766, AZD3965, and 3-bromopyruvic acid for 30 min, and then incubated for 2 h with CuO-NPs (20 μg/mL). The results showed that 3PO significantly inhibited the release of HETs.

  • 1/16

    3PO purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2021 Nov 3;69(43):12862-12869. [Abstract]

    Customer Validation
     T-2-triggered HET formation is dependent on PFKFB3, lactate transport, and hexokinase II. Heterophils were stimulated with T-2 (80 ng/mL) for 90 min in the inhibitors 3PO (24 μM), AZD3965, and 3-Bromopyruvic (n = 5). Zymosan (1 mg/mL) was the positive control. The results showed that 3PO significantly inhibited HET formation.

  • 3PO