1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR

AST2818 mesylate 

Cat. No.: HY-112870A
Handling Instructions

AST2818 mesylate is an EGFR inhibitor.

For research use only. We do not sell to patients.

AST2818 mesylate Chemical Structure

AST2818 mesylate Chemical Structure

CAS No. : 2130958-55-1

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AST2818 mesylate is an EGFR inhibitor.

IC50 & Target[1]

EGFR

 

In Vitro

AST2818 mesylate is designed to inhibit EGFR active mutations as well as the T790M acquired resistant mutation[1].

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (7.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5044 mL 7.5222 mL 15.0444 mL
5 mM 0.3009 mL 1.5044 mL 3.0089 mL
10 mM 0.1504 mL 0.7522 mL 1.5044 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (0.75 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (0.75 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.5 mg/mL (0.75 mM); Clear solution

References
Molecular Weight

664.70

Formula

C₂₉H₃₅F₃N₈O₅S

CAS No.

2130958-55-1

SMILES

C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(CCN(C)C)C)=O.CS(=O)(O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
AST2818 mesylate
Cat. No.:
HY-112870A
Quantity:

AST2818 mesylate

Cat. No.: HY-112870A