1. Metabolic Enzyme/Protease
  2. Aldehyde Dehydrogenase (ALDH)
  3. Alda-1

Alda-1 

Cat. No.: HY-18936 Purity: 99.81%
Handling Instructions

Alda-1 is a potent ALDH2 agonist, which activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2.

For research use only. We do not sell to patients.

Alda-1 Chemical Structure

Alda-1 Chemical Structure

CAS No. : 349438-38-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 78 In-stock
Estimated Time of Arrival: December 31
50 mg USD 156 In-stock
Estimated Time of Arrival: December 31
100 mg USD 252 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 8 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Alda-1 purchased from MCE. Usage Cited in: J Immunol Res. 2018 Dec 24;2018:9807139.

    Western blot assays show that 3-MA abrogates the Alda-1 induced expression increases in LC3BⅡ and Bcl2 and decreases in P62 and Bax.

    Alda-1 purchased from MCE. Usage Cited in: J Immunol Res. 2018 Dec 24;2018:9807139.

    Western blot analysis of p-AMPK, AMPK, Bcl2 and Bax, LC3B and P62 expression in liver tissues.

    Alda-1 purchased from MCE. Usage Cited in: Life Sci. 2018 Dec 15;215:227-235.

    VEGF-α representative western blot and relative density of immunoblot in DMSO group and Alda1-treated group at 1 d, 7 d and 30 d post aged diabetic rats model established.
    • Biological Activity

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    • References

    • Customer Review

    Description

    Alda-1 is a potent ALDH2 agonist, which activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2.

    IC50 & Target

    ALDH2[1]

    In Vivo

    Alda-1 treatment results in a significant decrease of 4-HNE-protein content in the plasma of apoE−/− mice. Alda-1 administration leads to a slight increase in gene expression related to neurogenesis (Nog), mitochondrial biogenesis (CYTB, ND1), and apoptosis (Bax, Gsk3b) in the Hp of apoE−/− mice. Alda-1 administration leads to 2 and 10 differentially expressed proteins in the FCx and Hp of apoE−/− mice, respectively[1]. Alda-1 (1.5 mg/kg, b.w., i.p.) administration significantly increases the climbing time, tends to reduce the immobility time and increases the swimming time of the prenatally stressed rats in the forced swim test. Moreover, treatment of prenatally stressed rats with Alda-1 significantly increases number of entries into the open arms of the maze and the time spent therein, as assessed by elevated plus-maze test[2]. Alda-1 (8.5 mg/kg, i.p.) with glucose significantly lowers 4-HNE and FJB-positive cells in the cerebral cortex of Alda-1-treated rats than in DMSO-treated rats 24 h after glucose administration[3]. Alda-1 (10 mg/kg per day) treatment prevents aldehydic overload, mitochondrial dysfunction and improves ventricular function in post-MI cardiomyopathy rats[4].

    Molecular Weight

    324.16

    Formula

    C₁₅H₁₁Cl₂NO₃

    CAS No.

    349438-38-6

    SMILES

    O=C(NCC1=CC=C(OCO2)C2=C1)C3=C(Cl)C=CC=C3Cl

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 51 mg/mL (157.33 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0849 mL 15.4245 mL 30.8490 mL
    5 mM 0.6170 mL 3.0849 mL 6.1698 mL
    10 mM 0.3085 mL 1.5424 mL 3.0849 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Alda-1 is dissolved in solution (5% DMSO+45% PEG400+water)[5].

    References
    Cell Assay
    [2]

    Spleen cells (4×106 cells/mL) are stimulated by optimal concentrations of concanavalin A (Con A; 2.5 μg/mL and 0.6 μg/mL) and lipopolysaccharide (LPS, 5 μg/mL) and are incubated in 96-well plates at final volume of 0.2 mL for 72 h. Cell proliferation is determined by adding 0.5 μCi of [3H]-thymidine per well at 16 h before the end of the incubation. The cultures are harvested with an automatic cell harvester, and [3H] thymidine incorporation is assessed using a liquid scintillation counter.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration
    [2]

    After behavioral verification at three months of age, the animals are divided into the following four groups: control, control + Alda-1, prenatally stressed and prenatally stressed + Alda-1 (6 animals per group). Alda-1 injections are given intraperitoneally (i.p.) once daily at a dose of 1.5 mg/kg b.w. (dissolved in 1 mL/kg b.w. DMSO/water 50/50) for 14 days. At the same time, the control and prenatally stressed rats receive 1 mL/kg b.w. DMSO/water 50/50. The injections of Alda-1 and vehicle are given between 10 a.m and 11 a.m. In the last five days of Alda-1 treatment the behavioral parameters in the elevated plus maze test and then in the forced swim test are measured.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
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    Product Name:
    Alda-1
    Cat. No.:
    HY-18936
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