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EC0489 

Cat. No.: HY-114306
Handling Instructions

EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor. Small molecule-drug conjugate (SMDC).

For research use only. We do not sell to patients.

EC0489 Chemical Structure

EC0489 Chemical Structure

CAS No. : 1096702-14-5

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  • Biological Activity

  • Technical Information

  • References

Description

EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor[1]. Small molecule-drug conjugate (SMDC)[2].

IC50 & Target

Folate receptor[1]

In Vitro

The affinity of EC0489 toward the folate receptor (FR) is approximately half of that of folic acid (relative affinity 0.50)[1].

FR-positive KB cells are highly sensitive to EC0489 with an IC50 of 5 nM[1].

In Vivo

EC0489 has a favorable toxicology profile in Rats. EC0489 (2, 3, and 4 μmol/kg) has antitumor activity against mice KB tumor models in a dose-dependent manner[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3921 mL 1.9603 mL 3.9205 mL
5 mM 0.0784 mL 0.3921 mL 0.7841 mL
10 mM 0.0392 mL 0.1960 mL 0.3921 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

2550.68

Formula

C₁₁₁H₁₅₆N₂₂O₄₃S₂

CAS No.

1096702-14-5

SMILES

[{Ggu}-QEQEQC]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
EC0489
Cat. No.:
HY-114306
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EC0489

Cat. No.: HY-114306