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FTBMT 

Cat. No.: HY-101787 Purity: 99.96%
Handling Instructions

FTBMT is a selective GPR52 agonist with an EC50 of 75 nM. Antipsychotic and procognitive properties.

For research use only. We do not sell to patients.

FTBMT Chemical Structure

FTBMT Chemical Structure

CAS No. : 1358575-02-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
25 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 640 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

FTBMT is a selective GPR52 agonist with an EC50 of 75 nM[1]. Antipsychotic and procognitive properties[2].

IC50 & Target

IC50: 75 nM (GPR52)[1]

In Vitro

FTBMT (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50s of 7.03, 6.85, and 6.87, respectively[2].

Cell Viability Assay[1]

Cell Line: CHO cells (expressing GPR52 receptors) cAMP assay
Concentration: 0.1-10 μM
Incubation Time: 30 minutes
Result: FTBMT activated cAMP signaling in vitro[1].
In Vivo

FTBMT (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice[2].

FTBMT (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats[2].

FTBMT (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition[2].

Animal Model: Male Long-Evans rats (9 weeks old)[2]
Dosage: 10 mg/kg
Administration: Oral, 1 hour before memory test
Result: A 1-hour pretreatment with FTBMT (10 mg/kg, p.o.) significantly decreases the number of memory errors induced by MK-801[2].
Animal Model: Male ICR mice (7 to 8 weeks old)[2]
Dosage: 3–30 mg/kg
Administration: Oral, 60 minutes before s.c. administration of MK-801
Result: FTBMT increases phospho-DARPP32 levels in the NAc slices[2].
Molecular Weight

392.35

Formula

C₁₉H₁₆F₄N₄O

CAS No.

1358575-02-6

SMILES

O=C(N)C1=CC=C(N2C(C)=NC(CC3=CC(C(F)(F)F)=CC(F)=C3)=N2)C=C1C

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (318.59 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5487 mL 12.7437 mL 25.4874 mL
5 mM 0.5097 mL 2.5487 mL 5.0975 mL
10 mM 0.2549 mL 1.2744 mL 2.5487 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.30 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.30 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.96%

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FTBMT
Cat. No.:
HY-101787
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