1. Cell Cycle/DNA Damage
    NF-κB
    Stem Cell/Wnt
  2. PPAR
    Wnt

JW74 (Synonyms: JW-74; JW 74)

Cat. No.: HY-19739 Purity: 99.93%
Data Sheet SDS Handling Instructions

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM.

For research use only. We do not sell to patients.
JW74 Chemical Structure

JW74 Chemical Structure

CAS No. : 863405-60-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $88 In-stock
5 mg $80 In-stock
10 mg $120 In-stock
25 mg $240 In-stock
50 mg $400 In-stock
100 mg $700 In-stock
200 mg   Get quote  
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Description

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM. IC50 value: 790 nM Target: Wnt JW74 increases concentration of AXIN2 and decrease the active form of β-catenin in SW480 colorectal cancer cells. [2] The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines.[1]

References
M.Wt

456.52

Formula

C₂₄H₂₀N₆O₂S

CAS No.

863405-60-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
JW74
Cat. No.:
HY-19739
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