Sapindaceae Extract

Gondoic acid (cis-11-Eicosenoic acid), a monounsaturated long-chain fatty acid, is contained in a variety of plant oils and nuts. Gondoic acid can exert anti-inflammatory activity by inhibiting the production of ROS and the PKCθ/ERK/STAT3 signaling pathway. Gondoic acid can be used as a raw material for medical supplies and a moisturizing ingredient in cosmetic creams.

Leucocyanidin is an active anti-ulcerogenic ingredient was extracted from Litchi Chinensis. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models.

Chinese gallotannin is a non-specific promiscuous α-amylase inhibitor with a K_i of 0.82 μg/mL for human salivary α-amylase. Chinese gallotannin can be used for the research of diabetes.

Dodovisone B is an isoprenylated flavonoid, that can be isolated from the aerial parts of Dodonaea viscosa.

Santin is a flavonol isolated from Dodonaea uscosa.

Ginnalin A (Acertannin) is an inducer of apoptosis and an activator of Nrf2. Ginnalin A binds to the Kelch sub-pocket of Keap1, disrupting the Keap1-Nrf2 interaction, which promotes the nuclear translocation of Nrf2 and the expression of antioxidant genes. Ginnalin A induces apoptosis and inhibits proliferation in hepatocellular carcinoma and other cancer cells; it also exhibits cytotoxicity against leukemia and melanoma cells and suppresses the growth of colon cancer. Furthermore, Ginnalin A acts as a free radical scavenger and a chelator of ferrous/cuprous ions. It inhibits TRAIL-induced apoptosis and oxidative/nitrosative stress in keratinocytes, suppresses tyrosinase activity and melanogenesis-related genes in melanoma cells, competitively inhibits collagenase (reducing MMP-13 and MMP-9 levels), and binds to amyloid-β monomers to inhibit their aggregation. Ginnalin A is a potential subject of research for hepatocellular carcinoma, colon cancer, various other cancers, Parkinson’s disease, Alzheimer’s disease, and skin aging.

Dimocarpus longan extract is an extract isolated fromDimocarpus longan.

Dimocarpus longan polysaccharide is a polysaccharide derived from Dimocarpus longan.

Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity.

Dihydromyrcene is a volatile terpenoid compound found in essential oil from Rosa indica L. petals. Dihydromyrcene has potential vasorelaxant and antispasmodic effects.

Kaempferol 7-O-neohesperidoside is a ?avonoid glycoside that can be isolated from Litchi chinensis. Kaempferol 7-O-neohesperidoside exhibits significant cytotoxic activity against A549, LAC, Hep-G2, and HeLa cell lines with IC₅₀s of 0.53, 7.93, 0.020, and 0.051 μM, respectively.

Aesculus wilsonii seeds polysaccharide is a polysaccharide derived from Aesculus wilsonii seeds.

Xanthoceras sorbifolium polysaccharide is a polysaccharide derived from Xanthoceras sorbifolium.

Aesculus chinensis polysaccharide is a polysaccharide derived from Aesculus chinensis.

Sapindus mukorossi polysaccharide is a polysaccharide derived from Sapindus mukorossi.

Pinocembrin-7-O-gentiobioside is a flavanone disaccharide glycoside that can be found in the seeds of Litchi chinensis Sonn.

Mukurozioside IIa is a sesquiterpene glycoside found in S. mukorossi. Mukurozioside IIa can be used for the research of breast cancer.

Mukurozioside IIb is a sesquiterpene glycoside found in S. mukorossi and Sapindus rarak. Mukurozioside IIb can be used for the research of breast cancer.

Mukurozioside Ia is an acyclic sesquiterpene oligoglycoside found in the pericarps of Sapindus rarak. Mukurozioside Ia can be used in the study of metabolic diseases.

Monodesmoside saponin C is an absorption enhancer. Monodesmoside saponin C promotes the absorption of poorly absorbable β-lactam antibiotics in the small intestine and rectum of rats. Monodesmoside saponin C has the ability to chelate Ca²⁺. The absorption-enhancing activity of Monodesmoside saponin C is inhibited by coexisting Ca²⁺ ions. Monodesmoside saponin C can be used in studies on absorption enhancement of β-lactam antibiotics.