SLIGRL-NH2
Based on 2 publication(s) in Google Scholar
SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.39%
- CAS. Nr.: 171436-38-7
- Formel: C29H56N10O7
- Molecular Weight:656.82
-
Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SLIGRL-NH2
More
Biologische Aktivität
PAR-2[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | EC50 |
4.2 μM
Compound: 1
|
Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium release
Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium release
|
[PMID: 23895492] |
| HT-29 | EC50 |
4.2 μM
Compound: SLIGRL-NH2
|
Agonist activity at PAR2 expressed in human HT29 cells assessed as intracellular calcium release
Agonist activity at PAR2 expressed in human HT29 cells assessed as intracellular calcium release
|
[PMID: 17765542] |
SLIGRL-NH2 is an agonist of PAR-2 and MrgprC11[1]. SLIGRL-NH2 causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH2 causing a concentration-dependent relaxation with an EC50 of 10 μM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 μM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 171436-38-7
-
Appearance Solid
-
Molecular Weight 656.82
-
Formel C29H56N10O7
-
Color White to off-white
-
Synonyms
Protease-Activated Receptor-2 Activating Peptide
-
Sequence
Ser-Leu-Ile-Gly-Arg-Leu-NH2
-
Sequence Shortening
SLIGRL-NH2
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Aging Cell
PAR2-mediated cellular senescence promotes inflammation and fibrosis in aging and chronic kidney disease. [Abstract]2024 Aug;23(8):e14184. PMID: 38687090 -
Biomolecules
PAR2 Participates in the Development of Cough Hypersensitivity in Guinea Pigs by Regulating TRPA1 Through PKC. [Abstract]2025 Feb 1;15(2):208. PMID: 40001511
Reinheit & Dokumentation
-
Data Sheet (272 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Akiyama T, et al. Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlativeresponses of lumbar dorsal horn neurons in the mouse. Neuroscience. 2014 Apr 25;266:38-46. [Content Brief]
[2]. Li Y, et al. Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms. Br J Pharmacol. 2011 Dec;164(8):1990-2002. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SLIGRL-NH2 Related Classifications
HY-P1308 Related Classifications
Powered by Bioz