2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. SLIGRL-NH2

SLIGRL-NH2  (Synonyms: Protease-Activated Receptor-2 Activating Peptide)

Cat. No.: HY-P1308 Purity: 99.78%
COA Handling Instructions

SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

SLIGRL-NH2 Chemical Structure

SLIGRL-NH2 Chemical Structure

CAS No. : 171436-38-7

Size Price Stock Quantity
Solution
10 mM * 1 mL USD 275 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 275 In-stock
Solid
1 mg USD 70 In-stock
5 mg USD 190 In-stock
10 mg USD 300 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2)[1].

IC50 & Target

PAR-2[1]
In Vitro

SLIGRL-NH2 is an agonist of PAR-2 and MrgprC11[1]. SLIGRL-NH2 causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH2 causing a concentration-dependent relaxation with an EC50 of 10 µM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 µM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

656.82

Appearance

Solid

Formula

C29H56N10O7
CAS No.
Sequence

Ser-Leu-Ile-Gly-Arg-Leu-NH2
Sequence Shortening

SLIGRL-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

H2O : 110 mg/mL (167.47 mM; Need ultrasonic)

DMSO : 100 mg/mL (152.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5225 mL 7.6124 mL 15.2249 mL
5 mM 0.3045 mL 1.5225 mL 3.0450 mL
10 mM 0.1522 mL 0.7612 mL 1.5225 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (152.25 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.81 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.81 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.78%

COA (248 KB) LCMS (264 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SLIGRL-NH2171436-38-7Protease-Activated Receptor-2 Activating PeptideProtease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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