1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)

SLIGRL-NH2 (Synonyms: Protease-Activated Receptor-2 Activating Peptide)

Cat. No.: HY-P1308 Purity: 99.66%
Handling Instructions

SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

SLIGRL-NH2 Chemical Structure

SLIGRL-NH2 Chemical Structure

CAS No. : 171436-38-7

Size Price Stock Quantity
10 mM * 1 mL USD 275 In-stock
Estimated Time of Arrival: December 31
1 mg USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 190 In-stock
Estimated Time of Arrival: December 31
10 mg USD 330 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SLIGRL-NH2:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2)[1].

IC50 & Target


In Vitro

SLIGRL-NH2 is an agonist of PAR-2 and MrgprC11[1]. SLIGRL-NH2 causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH2 causing a concentration-dependent relaxation with an EC50 of 10 µM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 µM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight








Sequence Shortening



Room temperature in continental US; may vary elsewhere.

Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 110 mg/mL (167.47 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5225 mL 7.6124 mL 15.2249 mL
5 mM 0.3045 mL 1.5225 mL 3.0450 mL
10 mM 0.1522 mL 0.7612 mL 1.5225 mL
*Please refer to the solubility information to select the appropriate solvent.

Purity: 99.66%

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SLIGRL-NH2Protease-Activated Receptor-2 Activating PeptideProtease-Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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