2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. SLIGRL-NH2

SLIGRL-NH2  (Synonyms: Protease-Activated Receptor-2 Activating Peptide)

Cat. No.: HY-P1308 Purity: 99.39%
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SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2).

For research use only. We do not sell to patients.

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SLIGRL-NH2

SLIGRL-NH2 Chemical Structure

CAS No. : 171436-38-7

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Based on 2 publication(s) in Google Scholar

Other Forms of SLIGRL-NH2:

SLIGRL-NH2 Related Antibodies

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Description

SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2)[1].

IC50 & Target

PAR-2[1]
Cellular Effect
Cell Line Type Value Description References
HT-29 EC50
4.2 μM
Compound: 1
Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium release
Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium release
[PMID: 23895492]
HT-29 EC50
4.2 μM
Compound: SLIGRL-NH2
Agonist activity at PAR2 expressed in human HT29 cells assessed as intracellular calcium release
Agonist activity at PAR2 expressed in human HT29 cells assessed as intracellular calcium release
[PMID: 17765542]
In Vitro

SLIGRL-NH2 is an agonist of PAR-2 and MrgprC11[1]. SLIGRL-NH2 causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH2 causing a concentration-dependent relaxation with an EC50 of 10 μM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 μM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SLIGRL-NH2 Related Antibodies
Molecular Weight

656.82

Formula

C29H56N10O7
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ser-Leu-Ile-Gly-Arg-Leu-NH2
Sequence Shortening

SLIGRL-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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SLIGRL-NH2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLIGRL-NH2171436-38-7Protease-Activated Receptor-2 Activating PeptideProtease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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