SLIGRL-NH2 TFA
Based on 2 publication(s) in Google Scholar
SLIGRL-NH2 TFA (Protease-Activated Receptor-2 Activating Peptide TFA) is an agonist of Protease-Activated Receptor-2 (PAR-2).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2828432-39-7
- 分子式: C31H57F3N10O9
- 分子量:770.84
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 SLIGRL-NH2 TFA
More
Customer Validation & Images
-
Cell Imaging/Staining
-
WB
生物活性
製品説明
IC50 & Target
PAR-2[1]
体外実験
SLIGRL-NH2 is an agonist of PAR-2 and MrgprC11[1]. SLIGRL-NH2 causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH2 causing a concentration-dependent relaxation with an EC50 of 10 μM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 μM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 2828432-39-7
-
分子量 770.84
-
分子式 C31H57F3N10O9
-
別名
Protease-Activated Receptor-2 Activating Peptide TFA
-
配列
Ser-Leu-Ile-Gly-Arg-Leu-NH2
-
シーケンスの短縮
SLIGRL-NH2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Aging Cell
PAR2-mediated cellular senescence promotes inflammation and fibrosis in aging and chronic kidney disease. [Abstract]2024 Aug;23(8):e14184. PMID: 38687090
SLIGRL-NH2 TFA purchased from MedChemExpress. Usage Cited in: Aging Cell. 2024 Aug;23(8):e14184. [Abstract]
SLIGRL‐NH2 (SLI: 150 μM、24 h). Representative images of SA‐β‐gal staining with or without PAR2 activation.
SLIGRL-NH2 TFA purchased from MedChemExpress. Usage Cited in: Aging Cell. 2024 Aug;23(8):e14184. [Abstract]
SLIGRL‐NH2 (SLI: 150 μM、24 h). Western blots show protein levels of p53 and p21 with or without PAR2 activation.
-
Biomolecules
PAR2 Participates in the Development of Cough Hypersensitivity in Guinea Pigs by Regulating TRPA1 Through PKC. [Abstract]2025 Feb 1;15(2):208. PMID: 40001511
溶剤 & 溶解度
体外
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
| Contents | Assign value | |
|---|---|---|
| Acidic amino acid | Asp (D), Glu (E), and the C-terminal -COOH. | -1 |
| Basic amino acid | Arg (R), Lys (K), His (H), and the N-terminal -NH2 | +1 |
| Neutral amino acid | Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) | 0 |
3. Recommended solution:
| Overall charge of peptide | Details |
|---|---|
| Negative (<0) |
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
| Positive (>0) |
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
| Zero (=0) |
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
純度とドキュメンテーション
参考文献
[1]. Akiyama T, et al. Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlativeresponses of lumbar dorsal horn neurons in the mouse. Neuroscience. 2014 Apr 25;266:38-46. [Content Brief]
[2]. Li Y, et al. Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms. Br J Pharmacol. 2011 Dec;164(8):1990-2002. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SLIGRL-NH2 TFA 関連分類
HY-P1308A 関連分類
Powered by Bioz