2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-129934
    Latanoprost ethyl amide 607351-44-0 98%
    Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.
    Latanoprost ethyl amide
  • HY-13017R
    Ivacaftor (Standard) 873054-44-5 98%
    Ivacaftor (Standard) is the analytical standard of Ivacaftor. This product is intended for research and analytical applications. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.
    Ivacaftor (Standard)
  • HY-131383
    Propoxyphenyl Aildenafil 1391053-82-9 98%
    Propoxyphenyl Aildenafil is a Sildenafil analogue. Propoxyphenyl Aildenafil can be used for the research of enhancement of sexual function.
    Propoxyphenyl Aildenafil
  • HY-13203R
    NVP-TAE 226 (Standard) 761437-28-9 98%
    NVP-TAE 226 (Standard) is the analytical standard of NVP-TAE 226. This product is intended for research and analytical applications. NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively.
    NVP-TAE 226 (Standard)
  • HY-13209R
    Ambrisentan (Standard) 177036-94-1 98%
    Ambrisentan (Standard) is the analytical standard of Ambrisentan. This product is intended for research and analytical applications. Ambrisentan is a selective ET type A receptor (ETAR) antagonist.
    Ambrisentan (Standard)
  • HY-13213A
    AM211 sodium 1263077-74-2 98%
    AM211 sodium is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
    AM211 sodium
  • HY-13331R
    Clascoterone (Standard) 19608-29-8
    Clascoterone (Standard) is the analytical standard of Clascoterone. This product is intended for research and analytical applications. Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist.
    Clascoterone (Standard)
  • HY-134108
    (3E,13Z)-Octadecadien-1-ol 66410-28-4 98%
    (3E,13Z)-Octadecadien-1-ol is a female sex pheromone attracting males, isolated from female Sequoia resin moths (Synanthedon sequoiae).
    (3E,13Z)-Octadecadien-1-ol
  • HY-134224
    Arachidonoyl 2'-fluoroethylamide 166100-37-4 98%
    Arachidonoyl 2'-fluoroethylamide is an anandamide analog. Arachidonoyl 2'-fluoroethylamide has the potential for the research of intraocular hypertension.
    Arachidonoyl 2'-fluoroethylamide
  • HY-13448R
    Nedocromil (Standard) 69049-73-6 98%
    Nedocromil (Standard) is the analytical standard of Nedocromil. This product is intended for research and analytical applications. Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
    Nedocromil (Standard)
  • HY-135004
    SU-4029 dihydrochloride 3194-36-3 98%
    Su-4029 is an agent that interacts with alpha receptors. It negates the blockade of norepinephrine by the reversible adrenergic blocker phentolamine but not by the irreversible blocker Dibenamine, suggesting Su-4029 acts at the same site as these blockers. Su-4029 pretreatment results in three categories of responses to pressor phenylalkylamines: irreversible blockade of amines with no or only p-hydroxylation, reversible blockade of amines with beta-carbon hydroxylation, and no blockade or augmentation of amines with m and p-hydroxylation or m or p plus beta-hydroxylation. Su-4029 may deform the alpha receptor site affected by adrenergic blocking agents.
    SU-4029 dihydrochloride
  • HY-135061
    20α-Dihydro prednisolone 15847-24-2 98%
    20α-Dihydro prednisolone is a metabolite of Prednisolone (HY-17463).
    20α-Dihydro prednisolone
  • HY-135580
    Raloxifene Bismethyl Ether 84541-38-8 98%
    Raloxifene Bismethyl Ether is a metabolite of Raloxifene and an estrogen receptor inactive compound on which both hydroxyl groups are absent.
    Raloxifene Bismethyl Ether
  • HY-135583
    LY88074 Trimethyl ether 63675-87-6 98%
    LY88074 Trimethyl ether (Example 1) is useful for the inhibition of the various estrogen deficient conditions, which are associated with estrogen deprivation syndrome including osteoporosis and hyperlipidemia.
    LY88074 Trimethyl ether
  • HY-13571R
    Betamethasone dipropionate (Standard) 5593-20-4 98%
    Betamethasone dipropionate (Standard) is the analytical standard of Betamethasone dipropionate. This product is intended for research and analytical applications. Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
    Betamethasone dipropionate (Standard)
  • HY-13673S
    Goserelin-d10 98%
    Goserelin-d10 (ICI 118630-d10) is deuterium labeled Goserelin. Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.
    Goserelin-d10
  • HY-136800
    Posatirelin 78664-73-0 98%
    Posatirelin, a TRH analog, increases monoamine metabolites in the cerebral cortex, nucleus accumbens, and striatum, and possibly exerts CNS activating effects through a modification of several neurotransmitter systems.
    Posatirelin
  • HY-13702R
    Nilutamide (Standard) 63612-50-0
    Nilutamide (Standard) is the analytical standard of Nilutamide. This product is intended for research and analytical applications. Nilutamide (Nilandron) is an orally active nonsteroidal androgen receptor antagonist with affinity for androgen receptors but not for progestogen, estrogen or glucocorticoid receptors. Nilutamide can be used to research prostate cancer. Nilutamide also has antischistosomal properties.
    Nilutamide (Standard)
  • HY-137043
    9-Keto Travoprost 1219032-18-4 98%
    9-Keto Travoprost is a derivative of Fluprostenol (HY-108560). 9-Keto Travoprost is an EP receptor agonist. 9-Keto Travoprost can be used in endocrine-related research.
    9-Keto Travoprost
  • HY-137089
    Azacosterol dihydrochloride 1249-84-9 98%
    Azacosterol (SC-12937) dihydrochloride is a chemosterilant which in-hibits reproduction in the pigeon. Azacosterol (SC-12937) dihydrochloride exerts its inhibitory effect through the blocking of the synthesis of cholesterol, thought to be a vital component in the formation of egg yolks.
    Azacosterol dihydrochloride
Cat. No. Product Name / Synonyms Application Reactivity