2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-165309
    UK-390957 364321-71-1 98%
    UK-390957 is a sulfonamide. UK-390957 binds to phosphatidylserine and carbonic anhydrase. UK-390957 can be used in the research of premature ejaculation.
    UK-390957
  • HY-16635R
    Setipiprant (Standard) 866460-33-5
    Setipiprant (Standard) is the analytical standard of Setipiprant. This product is intended for research and analytical applications. Setipiprant (ACT-129968) is an orally active and selective CRTH2 antagonist. Setipiprant interacts with hCRTH2 receptor with an IC50 value of 6 nM. Setipiprant inhibits prostanoid receptors hDP1 and hEP2 with IC50 values of 1290 and 2600 nM, respectively. Setipiprant can be used for the research of asthma and rhinitis.
    Setipiprant (Standard)
  • HY-16781R
    Grapiprant (Standard) 415903-37-6 98%
    Grapiprant (Standard) is the analytical standard of Grapiprant. This product is intended for research and analytical applications. Grapiprant (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor with IC50 value of 35 nM and Ki value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment .
    Grapiprant (Standard)
  • HY-168090
    Anti-osteoporosis agent-11 2869099-50-1 98%
    Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. Anti-osteoporosis agent-11 has the most significant inhibitory effect on osteoclast differentiation, with an IC50 value of 0.36 μM. In addition, Anti-osteoporosis agent-11 inhibits osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking rankl-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.
    Anti-osteoporosis agent-11
  • HY-168644
    Erα-IN-1 98%
    Erα-IN-1 (compound 3c) is an inhibitor of estrogen receptor α (ERα), blocking ERa activity in MCF7/ERE-LUC cells..
    Erα-IN-1
  • HY-168760
    (5α)-3,6-Dioxocholan-24-oic acid 6929-22-2 98%
    (5α)-3,6-Dioxocholan-24-oic acid is a secondary bile acid.
    (5α)-3,6-Dioxocholan-24-oic acid
  • HY-168799
    3-Methoxy prostaglandin F1α 54432-43-8 98%
    3-Methoxy prostaglandin F1α is an analog of PGF1α that can be metabolized by naturally occurring extracellular antibiotic resistance genes (eARGs) that enter the intestine via the food chain.
    3-Methoxy prostaglandin F1α
  • HY-168800
    19(R)-Hydroxy prostaglandin F1α 81371-59-7 98%
    19(R)-Hydroxy prostaglandin F1α is an ω-1 hydroxylase metabolite of PGF1α.
    19(R)-Hydroxy prostaglandin F1α
  • HY-16991R
    Terutroban (Standard) 165538-40-9 98%
    Terutroban (Standard) is the analytical standard of Terutroban. This product is intended for research and analytical applications. Terutroban (S-18886) is a selective and orally active thromboxane-prostaglandin (TP) receptor antagonist with an IC500 of 16.4 nM. Terutroban inhibits TXA2 and prostaglandin endoperoxide receptors. Terutroban is a potent antithrombotic agent and possesses antiatherosclerotic and antivasoconstrictor properties.
    Terutroban (Standard)
  • HY-17000R
    Tolvaptan (Standard) 150683-30-0 98%
    Tolvaptan (Standard) is the analytical standard of Tolvaptan. This product is intended for research and analytical applications. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation. Tolvaptan induces cell apoposis and affects cell cycle. Tolvaptan can be used for the research of hyponatremia.
    Tolvaptan (Standard)
  • HY-17000S
    Tolvaptan-d7 1246818-18-7 98%
    Tolvaptan-d7 is the deuterium labeled Tolvaptan. Tolvaptan is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation.
    Tolvaptan-d7
  • HY-17021A
    Esomeprazole magnesium salt 1198768-91-0 98%
    Esomeprazole magnesium salt ((S)-Omeprazole magnesium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole magnesium salt has the potential for symptomatic gastroesophageal reflux disease research.
    Esomeprazole magnesium salt
  • HY-17034R
    Medetomidine (Standard) 86347-14-0 98%
    Medetomidine (Standard) is the analytical standard of Medetomidine. This product is intended for research and analytical applications. Medetomidine is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine has sedative and analgesic effects. Medetomidine can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels.
    Medetomidine (Standard)
  • HY-17039R
    Alcaftadine (Standard) 147084-10-4
    Alcaftadine (Standard) is the analytical standard of Alcaftadine. This product is intended for research and analytical applications. Alcaftadine (R89674) is a histamine H1 receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis. Alcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. Alcaftadine also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects.
    Alcaftadine (Standard)
  • HY-17042R
    Cetirizine (Standard) 83881-51-0 98%
    Cetirizine (Standard) is the analytical standard of Cetirizine. This product is intended for research and analytical applications. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.
    Cetirizine (Standard)
  • HY-171248
    CDD-1115 3034215-86-3 98%
    CDD-1115 is a potent, selective inhibitor of BMPR2 with IC50 of 1.8 nM, Kiapp of 6.2 nM. CDD-1115 inhibits bone morphogenetic protein (BMP)-mediated gene expression. BMP controls cellular processes across many tissue types, including the kidney, skeletal muscle, heart, and reproductive organs. BMP induces ectopic bone formation.
    CDD-1115
  • HY-171612
    Follitropin alfa, Lutropin alfa (2:1) 98%
    Follitropin alfa, Lutropin alfa (2:1) is a combination of recombinant human follicle-stimulating hormone (Follitropin alfa, FSH) and recombinant human luteinizing hormone (Lutropin alfa, LH) in a 2:1 ratio. Follitropin alfa, Lutropin alfa (2:1) is a gonadotropin preparation used in assisted reproductive technology (ART) that is effective in achieving pregnancy with a good safety profile.
    Follitropin alfa, Lutropin alfa (2:1)
  • HY-172299
    Delmadinone acetate 13698-49-2 98%
    Delmadinone acetate is an orally active compound that can control estrus and ovulation in female and male pets. Delmadinone acetate causes adrenal suppression from inhibition of release of ACTH from the pituitary gland.
    Delmadinone acetate
  • HY-173215
    3-Dimethylaminopropyl deacetylforskolin 98%
    3-Dimethylaminopropyl deacetylforskolin is a dehydro derivative of adenylate cyclase activator Forskolin (HY-15371) and may cause cross-immunoreactivity with anti-Forskolin antibodies.
    3-Dimethylaminopropyl deacetylforskolin
  • HY-173271
    GHSR-1a agonist-1 3060887-25-1 98%
    GHSR-1a agonist-1 (Compound 4b) is an orally active agonist of the human growth hormone secretagogue receptor 1a (GHSR-1a), with an EC50 of 0.49 nM. GHSR-1a agonist-1 can effectively stimulate the release of endogenous growth hormone by activating GHSR-1a. GHSR-1a agonist-1 administered orally at a dose as low as 0.1 mg/kg can increase the body weight and body length of 4-week-old rats. GHSR-1a agonist-1 can be used in the research field of growth and development retardation in children.
    GHSR-1a agonist-1
Cat. No. Product Name / Synonyms Application Reactivity