2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Nom du produit CAS No. Pureté Chemical Structure
  • HY-100642S1
    3-O-Methyltolcapone-d4 2469274-07-3 98%
    3-O-Methyltolcapone-d4 (Ro 40-7591 d4) is a deuterium labeled 3-O-Methyltolcapone (HY-174062). 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone (HY-17406). Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma.
    3-O-Methyltolcapone-d4
  • HY-101392S1
    Harmane-d2 98%
    Harmane-d2 is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively).
    Harmane-d2
  • HY-104026S1
    L-Kynurenine-d4-1 194546-33-3 99.24%
    L-Kynurenine-d4-1 is deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
    L-Kynurenine-d4-1
  • HY-106224AS
    Orexin A-13C6,15N (human, rat, mouse) TFA
    Orexin A-13C6,15N (human, rat, mouse) (Hypocretin-1-13C6,15N (human, rat, mouse)) TFA is the 13C- and 15N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
    Orexin A-13C6,15N (human, rat, mouse) TFA
  • HY-107370AS
    (Rac)-Atomoxetine-d7 hydrochloride 2749423-74-1 98%
    (Rac)-Atomoxetine-d7 (hydrochloride) is a deuterium labeled (Rac)-Atomoxetine hydrochloride. (Rac)-Atomoxetine hydrochloride is a racemic form of Atomoxetine hydrochloride. Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).
    (Rac)-Atomoxetine-d7 hydrochloride
  • HY-108235S1
    (R)-Lanicemine-d5
    (R)-Lanicemine-d5 ((R)-AZd6765-d5) is the deuterium labeled (R)-Lanicemine (HY-108235C). (R)-Lanicemine ((R)-AZD6765) is the less active R-enantiomer of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1?μM for NMDA receptor; IC50s of 4-7?μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects.
    (R)-Lanicemine-d5
  • HY-108506S2
    Licarbazepine-d4-1 1188265-49-7 99.28%
    Licarbazepine-d4-1 is deuterium labeled Licarbazepine. Licarbazepine (BIA 2-005; GP 47779)?is a?voltage-gated sodium channel?blocker?with?anticonvulsant?and?mood-stabilizing?effects.
    Licarbazepine-d4-1
  • HY-110289S1
    (R)-Citalopram-d4 oxalate 2747918-87-0 98%
    (R)-Citalopram-d4 (oxalate) is deuterium labeled (R)-Citalopram Oxalate. (R)-Citalopram oxalate, a R-(-) enantiomers of Citalopram (HY-121203), is a serotonin reuptake inhibitor. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate can be used for research of depression.
    (R)-Citalopram-d4 oxalate
  • HY-111095BR
    D-(-)-Lactic acid sodium (Standard) 920-49-0 98%
    D-(-)-Lactic acid ((R)-2-Hydroxypropionic acid) sodium (Standard) is the analytical standard of Malvidin-3-glucoside sodium. This product is intended for research and analytical applications. D-(-)-Lactic acid sodium is an orally active, toxic optical isomer of Lactic acid (HY-B2227), mainly derived from overproduction by intestinal bacteria or exogenous intake. D-(-)-Lactic acid sodium can induce intoxication, characterized by severe metabolic acidosis accompanied by neurological symptoms.
    D-(-)-Lactic acid sodium (Standard)
  • HY-113050SA
    2,3-Diphosphoglyceric acid-d3 ammonium 2712139-19-8 98%
    2,3-Diphosphoglyceric acid-d3 ammonium (2,3-DPG-d3 ammonium) is the deuterium labeled 2,3-Diphosphoglyceric acid (HY-113050). 2,3-Diphosphoglyceric acid (2,3-DPG) is an intermediate of the glycolytic pathway. 2,3-Diphosphoglyceric acid stabilizes the deoxygenated form of hemoglobin by allosteric binding and facilitates oxygen release at tissue sites. 2, 3-diphosphoglyceric acid has antiparasitic activity. 2,3-Diphosphoglyceric acid can be used in the study of Alzheimer's disease (AD).
    2,3-Diphosphoglyceric acid-d3 ammonium
  • HY-113150S2
    Hexanoylglycine-13C2,15N 2483829-92-9
    Hexanoylglycine-13C2,15N is the 13C- and 15N-labeled Hexanoylglycine (HY-113150). Hexanoylglycine is an endogenous metabolite present in Urine that can be used for the research of Ethylmalonic Encephalopathy.
    Hexanoylglycine-13C2,15N
  • HY-113320S1
    Etiocholanolone-d2 2687960-82-1 98%
    Etiocholanolone-d2 is the deuterium labeled Etiocholanolone. Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity. Etiocholanolone is a less potent?neurosteroid positive allosteric modulator?(PAM) of the GABAA?receptor than its?enantiomer form.
    Etiocholanolone-d2
  • HY-113354S1
    Anserine-d4 hydrochloride 98%
    Anserine-d4 hydrochloride is the deuterium labeled Anserine (HY-113354). Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice.
    Anserine-d4 hydrochloride
  • HY-114118F5
    Semaglutide, Cy5 labeled 98%
    Semaglutide, Cy5 labeled is a CY5 (HY-D0821) labeled Semaglutide (HY-114118), which is suitable for high-sensitivity fluorescence detection and imaging (Ex/Em = 633/670 nm).
    Semaglutide, Cy5 labeled
  • HY-116016AR
    Etilevodopa hydrochloride (Standard) 39740-30-2 98%
    Etilevodopa (hydrochloride) (Standard) is the analytical standard of Etilevodopa (hydrochloride). This product is intended for research and analytical applications. Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine[1][2][3].
    Etilevodopa hydrochloride (Standard)
  • HY-116152S2
    Cipepofol-d6-2 2677052-87-6 98%
    Cipepofol-d6-2 (Ciprofol-d6-2; HSK3486-d6-2) is deuterium labeled Cipepofol (HY-116152). Cipepofol (HSK3486), a psychomotor stabilizing agent, is a gamma-aminobutyric acid (GABA) receptor potentiator.
    Cipepofol-d6-2
  • HY-116330AR
    Hyperforin dicyclohexylammonium salt (Standard) 238074-03-8
    Hyperforin dicyclohexylammonium salt (Standard) is the analytical standard of Hyperforin dicyclohexylammonium salt. This product is intended for research and analytical applications. Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.
    Hyperforin dicyclohexylammonium salt (Standard)
  • HY-116408AR
    Propiverine hydrochloride (Standard) 54556-98-8
    Propiverine (hydrochloride) (Standard) is the analytical standard of Propiverine (hydrochloride). This product is intended for research and analytical applications. Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.
    Propiverine hydrochloride (Standard)
  • HY-116408AS
    Propiverine-d7 hydrochloride 98%
    Propiverine-d7 (hydrochloride) is the deuterium labeled Propiverine hydrochloride. Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.
    Propiverine-d7 hydrochloride
  • HY-116755S2
    Tiropramide-d5 oxalate
    Tiropramide-d5 oxalate (CR 605-d5 oxalate) is the deuterium labeled Tiropramide oxalate. Tiropramide (CR 605) is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide relaxes smooth muscle in rabbit isolated colon. Tiropramide can be used for the research of irritable colon and biliary dyskinesia.
    Tiropramide-d5 oxalate
Cat. No. Nom du produit / Synonyms Application Reactivity