1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR

SCH 563705 

Cat. No.: HY-10011 Purity: 95.34%
Handling Instructions

SCH 563705 is a potent dual CXCR2(IC50= 1.3 nM)/CXCR1(IC50= 7.3 nM) antagonist.

For research use only. We do not sell to patients.

SCH 563705 Chemical Structure

SCH 563705 Chemical Structure

CAS No. : 473728-58-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 297 In-stock
Estimated Time of Arrival: December 31
2 mg USD 210 In-stock
Estimated Time of Arrival: December 31
5 mg USD 317 In-stock
Estimated Time of Arrival: December 31
10 mg USD 436 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

SCH 563705 is a potent dual CXCR2(IC50= 1.3 nM)/CXCR1(IC50= 7.3 nM) antagonist. IC50 value: 7.3 nM (CXCR1); 1.3 nM (CXCR2) [1] Target: CXCR1; CXCR2 in vitro: SCH 563705 has emerged as the most potent CXCR2–CXCR1 dual antagonist to date. It has been evaluated further in a wide range of in vitro and in vivo studies. In the chemotaxis assays, it demonstrated potent inhibition against both Gro-α and IL-8 induced human neutrophil migration (chemotaxis IC50 = 0.5 nM, against 30 nM of Gro-α; chemotaxis IC50 = 37 nM, against 3 nM of IL-8) [1]. SCH563705 selectively reduced the peripheral blood neutrophil frequency, and caused an elevation in the CXCR2 ligand CXCL1 [2]. in vivo: SCH 563705 achieved an ED50 of 0.9 mg/kg in the rat LPS (lipopolysaccharide) challenged model and an ED50 of 1 mg/kg in the mouse cigarette smoke induced neutrophilic inflammatory model [1].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (70.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3503 mL 11.7514 mL 23.5029 mL
5 mM 0.4701 mL 2.3503 mL 4.7006 mL
10 mM 0.2350 mL 1.1751 mL 2.3503 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

425.48

Formula

C₂₃H₂₇N₃O₅

CAS No.

473728-58-4

SMILES

O=C(C(NC1=CC=CC(C(N(C)C)=O)=C1O)=C2N[[email protected]](CC)C3=CC(C(C)C)=CO3)C2=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
SCH 563705
Cat. No.:
HY-10011
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SCH 563705

Cat. No.: HY-10011