2. Signaling Pathways
  3. GPCR/G Protein
    Immunology/Inflammation
  4. CXCR
  5. CXCR1 Isoform
  6. CXCR1 Antagonist

CXCR1 Antagonist

CXCR1 Antagonists (5):

Cat. No. Product Name Effect Purity
  • HY-10198
    Navarixin
    		Antagonist 99.13%
    Navarixin (SCH 527123) is a potent, allosteric and orally active antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly.
  • HY-120878
    CXCR2-IN-2
    		Antagonist 99.35%
    CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively).
  • HY-12927
    SX-517
    		Antagonist
    SX-517 is a dual CXCR2/1 antagonist, containing boronic acid.
  • HY-19519A
    Ladarixin sodium
    		Antagonist 99.15%
    Ladarixin sodium (DF 2156A) is an orally active, allosteric non-competitive and dual CXCR1 and CXCR2 antagonist.
  • HY-10011
    SCH 563705
    		Antagonist 98.20%
    SCH 563705 is a potent and orally available CXCR2 and CXCR1 antagonist, with IC50s of 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively.