473727-83-2
Chemical Structure
Navarixin
Synonym(s): SCH 527123; MK-7123
- CAS No.: 473727-83-2
- Formula:C21H23N3O5
- Molecular Weight:397.42
IUPAC Name: (R)-2-hydroxy-N,N-dimethyl-3-((2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)benzamide
InChIKey: RXIUEIPPLAFSDF-CYBMUJFWSA-N
SMILES: O=C1C(C(NC2=CC=CC(C(N(C)C)=O)=C2O)=C1N[C@H](CC)C3=CC=C(O3)C)=O
Biological Activity: Navarixin (SCH 527123) is a potent, allosteric and orally active antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Navarixin | 99.33% | Navarixin (SCH 527123) is a potent, allosteric and orally active antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly. | ||||||||||||||||||||
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Navarixin (Standard) | ≥98% | Navarixin (Standard) is the analytical standard of Navarixin (HY-10198). This product is intended for research and analytical applications. Navarixin (SCH 527123) is a potent, allosteric and orally active antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly. | ||||||||||||||||||||
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Similarity Score 0.86
HY-173491CXCR2/CCR7 antagonist-1 -
Similarity Score 0.81
HY-10011BR(Rac)-SCH 563705 (Standard) -
Similarity Score 0.81
HY-10011RSCH 563705 (Standard) -
Similarity Score 0.65
HY-162505SQA1 -
Similarity Score 0.57
HY-173052SLW131 -
Similarity Score 0.52
HY-148531PF-07054894 -
Similarity Score 0.50
HY-133073CCR7 Ligand 1 -
Similarity Score 0.46
HY-172587CB1R Allosteric modulator 5 -
Similarity Score 0.45
HY-169159SIRT6 activator 2 -
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References
- [1]. Gonsiorek W, et al. Pharmacological characterization of Sch527123, a potent allosteric CXCR1/CXCR2 antagonist. J Pharmacol Exp Ther. 2007 Aug;322(2):477-85. [Content Brief]
- [2]. Chapman RW, et al. A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation. J Pharmacol Exp Ther. 2007 Aug;322(2):486-93. [Content Brief]
