SLW131 

SLW131 is a CCR7 antagonist with a K_i value of 9.85 nM. SLW131 inhibits CCL19-induced Go protein activation with an IC₅₀ of 29.4 μM, and suppresses β-arrestin2 recruitment with an IC₅₀ of 6.0 μM. SLW131 serves as a probe for investigating the biological functions of CCR7 in cells. SLW131 is applicable to research related to rheumatoid arthritis^[1].

SLW131 (Compound 10) binds to the intracellular allosteric site of CCR7 in cell-free CCR7_GSSGNluc membranes with a single-digit nanomolar affinity (K_i = 9.85 nM), showing 10-fold higher potency than Cmp2105^[1].
SLW131 engages the intracellular allosteric site of CCR7 in live HEK293T cells transiently expressing CCR7^GSSG_Nluc with a single-digit nanomolar affinity (K_i = 6.53 nM), demonstrating improved cellular target engagement compared to Cmp2105^[1].
SLW131 inhibits CCL19-induced β-arrestin2 recruitment in HEK293T cells transiently expressing hCCR7, while Cmp2105 shows no inhibitory activity^[1].
SLW131 (10 μM; 1 h) inhibits CCL19-directed 3D collagen migration of primary mature BMDCs, while Cmp2105 shows no inhibitory activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

461.53

C₂₁H₂₇N₅O₅S

681511-84-2

O=C(C1=CC=CC(NC(C(N[C@H](C(C)(C)C)C2=CC=C(O2)C)=N3)=NS3(=O)=O)=C1O)N(C)C

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• [1]. Wurnig SL, et al. A Fluorescent Probe Enables the Discovery of Improved Antagonists Targeting the Intracellular Allosteric Site of the Chemokine Receptor CCR7. J Med Chem. 2025;68(4):4308-4333.  [Content Brief]