CXCR2/CCR7 antagonist-1
CXCR2/CCR7 antagonist-1 (compound 6) is a potent CXCR2 and CCR7 dual antagonist with IC50s of 0.0046 and 0.0014 μM, respectively. CXCR2/CCR7 antagonist-1 can be used in the study of cancer metastasis and autoimmune diseases.
For research use only. We do not sell to patients.
- CAS No.: 473728-04-0
- Formula: C23H27N3O5
- Molecular Weight:425.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
11 nM
Compound: 24
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Displacement of [125I]hCXCL8 from human CXCR1 receptor expressed in BaF3 cells
Displacement of [125I]hCXCL8 from human CXCR1 receptor expressed in BaF3 cells
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[PMID: 17181143] |
| BaF3 | IC50 |
3.8 nM
Compound: 24
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Displacement of [125I]hCXCL8 from human CXCR2 receptor expressed in BaF3 cells
Displacement of [125I]hCXCL8 from human CXCR2 receptor expressed in BaF3 cells
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[PMID: 17181143] |
Chemical Information
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CAS No. 473728-04-0
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Molecular Weight 425.48
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Formula C23H27N3O5
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SMILES
OC1=C(C(N(C)C)=O)C=CC=C1NC2=C(N[C@H](C(C)(C)C)C3=CC=C(C)O3)C(C2=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CXCR2/CCR7 antagonist-1 Related Classifications
HY-173491 Related Classifications
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