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dnmt3a-in-3

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-144433
    DNMT3A-IN-1

    		DNA Methyltransferase Infection
    DNMT3A-IN-1 is a potent and selective DNMT3A inhibitor. DNMT3A-IN-1 shows inhibitor activities against DNMT3A with kI values range from 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC) .
    <em>DNMT</em>3A-IN-1
  • HY-13962
    SGI-1027
    5+ Cited Publications

    		 DNA Methyltransferase Apoptosis Cancer
    SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate.
    SGI-1027
  • HY-101925
    CM-272
    1 Publications Verification

    		 Histone Methyltransferase DNA Methyltransferase Apoptosis Cancer
    CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor with antitumor activities. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing IFN-stimulated genes and immunogenic cell death .
    CM-272
  • HY-158165
    DNMT3A-IN-3

    		DNA Methyltransferase Cancer
    DNMT3A-IN-3 is an allosteric DNA methyltransferase 3A (DNMT3A) inhibitor. DNMT3A-IN-3 binds and disrupt protein-protein interactions (PPIs) at the DNMT3A tetramer interface .
    <em>DNMT3A-IN-3</em>
  • HY-158164
    DNMT3A-IN-2

    		DNA Methyltransferase Cancer
    DNMT3A-IN-2 (compound 1a) is a hydrophthalazinone-based inhibitor of DNA methyltransferase 3A (DNMT3A) (IC50: 14 μM) against S-adenosylmethionine (SAM) has a Ki of 9.16-18.85 μM. .
    <em>DNMT</em>3A-IN-2

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