Epoxide Hydrolase

Related Products

Epoxide hydrolases (EH) present in all living organisms. The mammalian soluble epoxide hydrolase (sEH) is a 120 kDa dimer of two identical 62.5 kDa monomers arranged in an anti-parallel fashion. It is mostly expressed in the liver, kidneys, brain, endothelium, and at lesser levels in other tissues. Inflammation and pain are major components of many disease states. Mammalian sEH inhibition reduces blood pressure, inflammation and pain. The anti-inflammatory activities of sEH inhibitors occur in part through the NF-κB mediated down-regulation of COX2 transcription, resulting in lower production of pro-inflammatory prostaglandins such as PGE2 and PGD2.

Epoxide Hydrolase Inhibitors (41)

Epoxide Hydrolase Related Products (44):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W403075

N-(3-Methoxybenzyl)stearamide	Inhibitor
N-(3-Methoxybenzyl)stearamide a natural product from Lepidium meyenii (Maca), inhibits human and mouse soluble epoxide hydrolase (hsEH and msEH) with IC₅₀s of 0.001 and <0.001 μg/nM, respectively.

HY-163401

Epoxykynin	Inhibitor
Epoxykynin is a potent epoxide hydrolase (sEH) inhibitor.

HY-151617

sEH inhibitor-11	Inhibitor
sEH inhibitor-11 (compound 35) is a sEH inhibitor with an IC₅₀ value of 0.3 μM. sEH inhibitor-11 can be used for the research of inflammation.

HY-U00453

Soluble epoxide hydrolase inhibitor	Inhibitor
Soluble epoxide hydrolase inhibitor is an inhibitor of soluble epoxide hydrolase, and inhibits human soluble epoxide hydrolase (h-sEH) with pIC₅₀ of 8.4, extracted from patent WO 2010096722 A1, example 57.

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