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Soluble epoxide hydrolase inhibitor 

Cat. No.: HY-U00453
Handling Instructions

Soluble epoxide hydrolase inhibitor is an inhibitor of soluble epoxide hydrolase, and inhibits human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4, extracted from patent WO 2010096722 A1, example 57.

For research use only. We do not sell to patients.

Soluble epoxide hydrolase inhibitor Chemical Structure

Soluble epoxide hydrolase inhibitor Chemical Structure

CAS No. : 1241826-88-9

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25 mg USD 2600 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Soluble epoxide hydrolase inhibitor is an inhibitor of soluble epoxide hydrolase, and inhibits human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4, extracted from patent WO 2010096722 A1, example 57.

IC50 & Target

pIC50: 8.4 (h-sEH)[1]

In Vitro

Soluble epoxide hydrolase inhibitor (Example 57) is an inhibitor of soluble epoxide hydrolase, and inhibits human soluble epoxide hydrolase with pIC50 of 8.4[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2660 mL 11.3299 mL 22.6598 mL
5 mM 0.4532 mL 2.2660 mL 4.5320 mL
10 mM 0.2266 mL 1.1330 mL 2.2660 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Kinase Assay
[1]

The sEH inhibitory properties of test compounds (including Soluble epoxide hydrolase inhibitor) are determined using a black 384-well-plate format under the following reaction conditions: 20 mM Tris pH 7.0, 0.1 mM EDTA, 0.1 mg/mL BSA, 5 μM PHOME (substrate), 2 nM sEH enzyme, 1% DMSO (from test compound). Reaction product is determined quantitatively by fluorescence intensity using a Fluorescence plate reader with an excitation wavelength at 330 nm and emission at 465 nm[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

441.31

Formula

C₁₈H₁₂F₅N₅O₃

CAS No.

1241826-88-9

SMILES

O=C(C1=CN2C(C=C1)=NN(CC(F)F)C2=O)NCC3=CC=C(C#N)C=C3OC(F)(F)F

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Soluble epoxide hydrolase inhibitor
Cat. No.:
HY-U00453
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Soluble epoxide hydrolase inhibitor

Cat. No.: HY-U00453