1. Cell Cycle/DNA Damage
  2. Deubiquitinase

VLX1570 

Cat. No.: HY-12471 Purity: 98.00%
Data Sheet SDS Handling Instructions

VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM.

For research use only. We do not sell to patients.
VLX1570 Chemical Structure

VLX1570 Chemical Structure

CAS No. : 1431280-51-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO $361 In-stock
1 mg $150 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

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Description

VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14. In vitor: VLX1570 was indeed found to inhibit USP14 in cells at a concentration of 1 uM. target: DUBs IC50: 4.2 uM to 8.6 uM In vitro: 1) VLX1570 inhibits proteasome deubiqu-itinase activity and induces accumulation of high molecularweight. polyubiquitinated proteins in cells. 2) Knock-down of USP14 in multiple myeloma cells induces loss of cell viability. 3) VLX1570 induces accumulation of polyubiquitin chains and elicits apoptosis of multiple myeloma cells. 4) VLX1570 induces apoptosis and cell death of MM cells In vivo: The reference for the injection is 5 mg/kg Note: The compound was dissolved in 50% PEG400/40%Tween-80/10% Kolliphor EL and then diluted with saline.

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References
Molecular Weight

469.39

Formula

C₂₃H₁₇F₂N₃O₆

CAS No.

1431280-51-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.00%

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Product Name:
VLX1570
Cat. No.:
HY-12471
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