Abacavir hydrochloride
Based on 8 publication(s) in Google Scholar
Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir hydrochloride can inhibits the replication of HIV. Abacavir hydrochloride shows anticancer activity in prostate cancer cell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppresses telomerase activity.
For research use only. We do not sell to patients.
- CAS No.: 136777-48-5
- Formula: C14H19ClN6O
- Molecular Weight:322.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Abacavir hydrochloride
More- Cancer Res. 2026 Jul 15;86(14):3588-3603.
- Adv Sci (Weinh). 2025 May 8:e2503579. [Abstract]
- Aging Cell. 2026 Jan 20;25(2):e70352.
- J Mol Liq. 2018 Feb;251:345-357.
- Int J Antimicrob Agents. 2019 Dec;54(6):814-819. [Abstract]
- Antiviral Res. 2023 Aug:216:105674. [Abstract]
- ASN Neuro. 2026;18(1):2647877. [Abstract]
- Virology. 2026 Jun 4:623:110991.
Biological Activity
Abacavir hydrochloride (15 and 150 μM, 0-120 h) inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines[1].
Abacavir hydrochloride (15 and 150 μM, 18 h) significantly reduces cell migration and inhibits cell invasion[1].
Abacavir hydrochloride induces fat apoptosis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3, LNCaP and WI-38
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Concentration:15 μM and 150 μM
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Incubation Time:0, 24, 48, 72 and 96 hours
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Result:Showed a dose-dependent growth inhibition on PC3 and LNCaP.
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Cell Line:PC3, LNCaP and WI-38
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Concentration:150 μM
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Incubation Time:0, 18, 24, 48, 72, 96 and 120 hours
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Result:Caused a very high accumulation of cells in S phase in PC3 and LNCaP cells, and G2/M phase increment was observed in PC3 cells.
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Cell Line:PC3, LNCaP and WI-38
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Concentration:15 and 150 μM
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Incubation Time:18 hours
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Result:Significantly reduced cell migration.
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Cell Line:PC3, LNCaP and WI-38
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Concentration:15 and 150 μM
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Incubation Time:18 hours
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Result:Significantly inhibited cell invision.
Abacavir hydrochloride (50 mg/kg/d; i.p.; 14 d) with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)[2]
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Dosage:Route 1: 2.5, 5, and 7.5 μg/mL, 100 μL
Route 2: 100 and 200 mg/kg -
Administration:Intrascrotal or oral administration for 4 h
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Result:Dose-dependently promoted thrombus formation.
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Animal Model:NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma[3]
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Dosage:50 mg/kg/d with 0.1 mg/kg/d Decitabine
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Administration:Intraperitoneal injection, daily for 14 days
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Result:Inhibited tumor growth and enhanced mouse survival.
Chemical Information
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CAS No. 136777-48-5
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Molecular Weight 322.79
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Formula C14H19ClN6O
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SMILES
NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](CO)C4)C3=N1.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (8)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Neuronal FGF13 Inhibits Mitochondria-Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease. [Abstract]2025 May 8:e2503579. PMID: 40344619 -
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Int J Antimicrob Agents
2019 Dec;54(6):814-819. PMID: 31479744 -
Antiviral Res
Seasonal coronavirus infections trigger NLRP3 inflammasome activation in macrophages but is therapeutically targetable. [Abstract]2023 Aug:216:105674. PMID: 37459896 -
ASN Neuro
Exposure to Frontline Antiretroviral Dolutegravir Disrupts Oligodendrocyte Development Across Differentiation Stages. [Abstract]2026;18(1):2647877. PMID: 41904696 -
Purity & Documentation
References
[1]. Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5(12):e14221. [Content Brief]
[2]. Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218(2):228-233. [Content Brief]
[3]. Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23(7):3815. [Content Brief]
[4]. McComsey GA, et al. Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS. 2005 Jan 3;19(1):15-23. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Abacavir hydrochloride Related Classifications
HY-17423E Related Classifications
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