1. Anti-infection Cell Cycle/DNA Damage Apoptosis
  2. Reverse Transcriptase HIV Telomerase Apoptosis
  3. Abacavir sulfate

Abacavir sulfate  (Synonyms: Abacavir Hemisulfate; ABC sulfate)

Cat. No.: HY-17423A Purity: 99.88%
COA Handling Instructions

Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity.

For research use only. We do not sell to patients.

Abacavir sulfate Chemical Structure

Abacavir sulfate Chemical Structure

CAS No. : 188062-50-2

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 55 In-stock
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10 mM * 1 mL in DMSO USD 55 In-stock
Solid
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10 mg USD 50 In-stock
50 mg USD 125 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Abacavir sulfate:

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Description

Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].

In Vitro

Abacavir (15 and 150 μM, 0-120 h) sulfate inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines[1].
Abacavir (15 and 150 μM, 18 h) sulfate significantly reduces cell migration and inhibits cell invasion[1].
Abacavir sulfate induces fat apoptosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: PC3, LNCaP and WI-38
Concentration: 15 and 150 μM
Incubation Time: 0, 24, 48, 72 and 96 h
Result: Showed a dose-dependent growth inhibition on PC3 and LNCaP.

Cell Cycle Analysis[1]

Cell Line: PC3 and LNCaP
Concentration: 150 μM
Incubation Time: 0, 18, 24, 48, 72, 96 and 120 h
Result: Caused a very high accumulation of cells in S phase in PC3 and LNCaP cells, and G2/M phase increment was observed in PC3 cells.

Cell Migration Assay [1]

Cell Line: PC3 and LNCaP
Concentration: 15 and 150 μM
Incubation Time: 18 h
Result: Significantly reduced cell migration.

Cell Invasion Assay[1]

Cell Line: PC3 and LNCaP
Concentration: 15 and 150 μM
Incubation Time: 18 h
Result: Significantly inhibited cell invision.
In Vivo

Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) sulfate dose-dependently promoted thrombus formation[2].
Abacavir (50 mg/kg/d; i.p.; 14 days) sulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)[2]
Dosage: 2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg
Administration: Intrascrotal or oral administration for 4 h
Result: Dose-dependently promoted thrombus formation.
Animal Model: NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma[3]
Dosage: 50 mg/kg/d with 0.1 mg/kg/d Decitabine
Administration: Intraperitoneal injection, daily for 14 days
Result: Inhibited tumor growth and enhanced mouse survival.
Clinical Trial
Molecular Weight

335.38

Appearance

Solid

Formula

C14H18N6O.1/2H2O4S

CAS No.
SMILES

O=S(O)(O)=O.NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](CO)C4)C3=N1.[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (149.08 mM; Need ultrasonic)

H2O : 33.33 mg/mL (99.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9817 mL 14.9085 mL 29.8169 mL
5 mM 0.5963 mL 2.9817 mL 5.9634 mL
10 mM 0.2982 mL 1.4908 mL 2.9817 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (29.82 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.45 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.45 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.88%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Abacavir sulfate
Cat. No.:
HY-17423A
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