Abacavir sulfate
Based on 9 publication(s) in Google Scholar
Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.93%
- CAS. Nr.: 188062-50-2
- Formel: C14H18N6O.1/2H2O4S
- Molecular Weight:335.38
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Speicherung:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-B0250
LamivudineReverse Transcriptase Inhibitor -
HY-17427
EmtricitabineNRT Inhibitor -
HY-15232A
Tenofovir alafenamide fumarateReverse Transcriptase Inhibitor -
HY-17413
ZidovudineNucleoside Reverse Transcriptase Inhibitor -
HY-13782
Tenofovir Disoproxil fumarateNucleotide Reverse Transcriptase Inhibitor -
HY-17423
AbacavirReverse Transcriptase Inhibitor -
HY-90005
Etravirine -
HY-13910
TenofovirNucleotide Reverse Transcriptase Inhibitor -
HY-13782A
Tenofovir DisoproxilReverse Transcriptase Inhibitor -
HY-17423AR
Abacavir sulfate (Standard)Reverse Transcriptase Inhibitor -
HY-17392
ZalcitabineReverse Transcriptase Inhibitor -
HY-15232
Tenofovir alafenamideReverse Transcriptase Inhibitor
Publications Citing Use of MedChemExpress (MCE) Abacavir sulfate
More- Cancer Res. 2026 Jul 15;86(14):3588-3603. [Abstract]
- Adv Sci (Weinh). 2025 Jul;12(28):e2503579. [Abstract]
- Aging Cell. 2026 Jan 20;25(2):e70352.
- Int J Antimicrob Agents. 2019 Dec;54(6):814-819. [Abstract]
- ASN Neuro. 2026;18(1):2647877. [Abstract]
- Antiviral Res. 2023 Aug:216:105674. [Abstract]
- Virology. 2026 Jun 4:623:110991. [Abstract]
- bioRxiv. 2026 Jul 18.
- J Mol Liq. 2018 Feb;251:345-357.
Biologische Aktivität
Beschreibung
In Vitro
Abacavir (15 and 150 μM, 0-120 h) sulfate inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines[1].
Abacavir (15 and 150 μM, 18 h) sulfate significantly reduces cell migration and inhibits cell invasion[1].
Abacavir sulfate induces fat apoptosis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:PC3, LNCaP and WI-38
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Concentration:15 and 150 μM
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Incubation Time:0, 24, 48, 72 and 96 h
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Result:Showed a dose-dependent growth inhibition on PC3 and LNCaP.
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Cell Line:PC3 and LNCaP
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Concentration:150 μM
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Incubation Time:0, 18, 24, 48, 72, 96 and 120 h
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Result:Caused a very high accumulation of cells in S phase in PC3 and LNCaP cells, and G2/M phase increment was observed in PC3 cells.
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Cell Line:PC3 and LNCaP
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Concentration:15 and 150 μM
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Incubation Time:18 h
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Result:Significantly reduced cell migration.
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Cell Line:PC3 and LNCaP
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Concentration:15 and 150 μM
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Incubation Time:18 h
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Result:Significantly inhibited cell invision.
In Vivo
Abacavir (50 mg/kg/d; i.p.; 14 days) sulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)[2]
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Dosage:2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg
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Administration:Intrascrotal or oral administration for 4 h
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Result:Dose-dependently promoted thrombus formation.
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Animal Model:NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma[3]
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Dosage:50 mg/kg/d with 0.1 mg/kg/d Decitabine
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Administration:Intraperitoneal injection, daily for 14 days
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Result:Inhibited tumor growth and enhanced mouse survival.
Chemical Information
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CAS. Nr. 188062-50-2
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Appearance Solid
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Molecular Weight 335.38
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Formel C14H18N6O.1/2H2O4S
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Color White to off-white
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SMILES
O=S(O)(O)=O.NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](CO)C4)C3=N1.[1/2]
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Synonyms
Abacavir Hemisulfate; ABC sulfate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications (9)
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Journal Impact Factor
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Most Recent
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Cancer Res
Targeting DOT1L Reactivates HERV-K to Drive Cell-Autonomous and Paracrine Senescence in Adenocarcinoma of the Esophagogastric Junction. [Abstract]2026 Jul 15;86(14):3588-3603. PMID: 42084229 -
Adv Sci (Weinh)
Neuronal FGF13 Inhibits Mitochondria-Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease. [Abstract]2025 Jul;12(28):e2503579. PMID: 40344619 -
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Int J Antimicrob Agents
2019 Dec;54(6):814-819. PMID: 31479744 -
ASN Neuro
Exposure to Frontline Antiretroviral Dolutegravir Disrupts Oligodendrocyte Development Across Differentiation Stages. [Abstract]2026;18(1):2647877. PMID: 41904696 -
Antiviral Res
Seasonal coronavirus infections trigger NLRP3 inflammasome activation in macrophages but is therapeutically targetable. [Abstract]2023 Aug:216:105674. PMID: 37459896 -
Virology
Generation and evaluation of an EcoHIV mouse model to study HIV-1 integration and expression. [Abstract]2026 Jun 4:623:110991. PMID: 42320113 -
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Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (149.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 33.33 mg/mL (99.38 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.45 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.45 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (29.82 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Reinheit & Dokumentation
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Data Sheet (283 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5(12):e14221. [Content Brief]
[2]. Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218(2):228-233. [Content Brief]
[3]. Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23(7):3815. [Content Brief]
[4]. McComsey GA, et al. Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS. 2005 Jan 3;19(1):15-23. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.9817 mL | 14.9085 mL | 29.8169 mL | 74.5423 mL |
| 5 mM | 0.5963 mL | 2.9817 mL | 5.9634 mL | 14.9085 mL | |
| 10 mM | 0.2982 mL | 1.4908 mL | 2.9817 mL | 7.4542 mL | |
| 15 mM | 0.1988 mL | 0.9939 mL | 1.9878 mL | 4.9695 mL | |
| 20 mM | 0.1491 mL | 0.7454 mL | 1.4908 mL | 3.7271 mL | |
| 25 mM | 0.1193 mL | 0.5963 mL | 1.1927 mL | 2.9817 mL | |
| 30 mM | 0.0994 mL | 0.4969 mL | 0.9939 mL | 2.4847 mL | |
| 40 mM | 0.0745 mL | 0.3727 mL | 0.7454 mL | 1.8636 mL | |
| 50 mM | 0.0596 mL | 0.2982 mL | 0.5963 mL | 1.4908 mL | |
| 60 mM | 0.0497 mL | 0.2485 mL | 0.4969 mL | 1.2424 mL | |
| 80 mM | 0.0373 mL | 0.1864 mL | 0.3727 mL | 0.9318 mL | |
| DMSO | 100 mM | 0.0298 mL | 0.1491 mL | 0.2982 mL | 0.7454 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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