Cat. No.: HY-17423B

Abacavir monosulfate

8 Cited Publications

Customer Review

Based on 8 publication(s) in Google Scholar

Abacavir monosulfate is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir monosulfate can inhibits the replication of HIV. Abacavir monosulfate shows anticancer activity in prostate cancer cell lines. Abacavir monosulfate can trespass the blood-brain-barrier and suppresses telomerase activity.

For research use only. We do not sell to patients.

Purity: 98.86%
CAS No.: 216699-07-9
Formula: C₁₄H₂₀N₆O₅S
Molecular Weight:384.41

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Abacavir monosulfate Chemical Structure

CAS No.: 216699-07-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (8)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All HIV Isoforms :

In Vitro

Abacavir (15 and 150 μM, 0-120 h) monosulfate inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines^[1].
Abacavir (15 and 150 μM, 18 h) monosulfate significantly reduces cell migration and inhibits cell invasion^[1].
Abacavir monsulfate induces fat apoptosis^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

PC3, LNCaP and WI-38
Concentration:

15 and 150 μM
Incubation Time:

0, 24, 48, 72 and 96 h
Result:

Showed a dose-dependent growth inhibition on PC3 and LNCaP.

Cell Cycle Analysis^[1]

Cell Line:

PC3 and LNCaP
Concentration:

150 μM
Incubation Time:

0, 18, 24, 48, 72, 96 and 120 h
Result:

Caused a very high accumulation of cells in S phase in PC3 and LNCaP cells, and G2/M phase increment was observed in PC3 cells.

Cell Migration Assay ^[1]

Cell Line:

PC3 and LNCaP
Concentration:

15 and 150 μM
Incubation Time:

18 h
Result:

Significantly reduced cell migration.

Cell Invasion Assay^[1]

Cell Line:

PC3 and LNCaP
Concentration:

15 and 150 μM
Incubation Time:

18 h
Result:

Significantly inhibited cell invision.

In Vivo

Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) monosulfate dose-dependently promoted thrombus formation^[2].
Abacavir (50 mg/kg/d; i.p.; 14 days) monosulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7^tm1Gab/J)^[2]
Dosage:

2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg
Administration:

Intrascrotal or oral administration for 4 h
Result:

Dose-dependently promoted thrombus formation.

Animal Model:

NSG^TM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma^[3]
Dosage:

50 mg/kg/d with 0.1 mg/kg/d Decitabine
Administration:

Intraperitoneal injection, daily for 14 days
Result:

Inhibited tumor growth and enhanced mouse survival.

Chemical Information

CAS No. 216699-07-9
Appearance Powder
Molecular Weight 384.41
Formula C₁₄H₂₀N₆O₅S
Color white
SMILES

NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](CO)C4)C3=N1.O=S(O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (8)

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Cancer Res

Targeting DOT1L Reactivates HERV-K to Drive Cell-Autonomous and Paracrine Senescence in Adenocarcinoma of the Esophagogastric Junction. [Abstract]

2026 Jul 15;86(14):3588-3603. PMID: 42084229
Adv Sci (Weinh)

Neuronal FGF13 Inhibits Mitochondria-Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease. [Abstract]

2025 May 8:e2503579. PMID: 40344619
Aging Cell

2026 Jan 20;25(2):e70352.
J Mol Liq

2018 Feb;251:345-357.
Int J Antimicrob Agents

Efficacy of antiretroviral compounds against Toxoplasma gondii in vitro. [Abstract]

2019 Dec;54(6):814-819. PMID: 31479744
Antiviral Res

Seasonal coronavirus infections trigger NLRP3 inflammasome activation in macrophages but is therapeutically targetable. [Abstract]

2023 Aug:216:105674. PMID: 37459896
ASN Neuro

Exposure to Frontline Antiretroviral Dolutegravir Disrupts Oligodendrocyte Development Across Differentiation Stages. [Abstract]

2026;18(1):2647877. PMID: 41904696
Virology

Generation and evaluation of an EcoHIV mouse model to study HIV-1 integration and expression. [Abstract]

2026 Jun 4:623:110991. PMID: 42320113

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5(12):e14221. [Content Brief]

[2]. Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218(2):228-233. [Content Brief]

[3]. Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23(7):3815. [Content Brief]

[4]. McComsey GA, et al. Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS. 2005 Jan 3;19(1):15-23. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Abacavir monosulfate

8 Cited Publications

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Abacavir monosulfate

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Publications Citing Use of MedChemExpress (MCE) Abacavir monosulfate

All HIV Isoforms

Biological Activity

Chemical Information

Publications (8)

Purity & Documentation

References

Calculators

Help & FAQs

Abacavir monosulfate Related Classifications

HY-17423B Related Classifications