Abacavir monosulfate
Based on 9 publication(s) in Google Scholar
Abacavir monosulfate is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir monosulfate can inhibits the replication of HIV. Abacavir monosulfate shows anticancer activity in prostate cancer cell lines. Abacavir monosulfate can trespass the blood-brain-barrier and suppresses telomerase activity.
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- Pureza : 98.86%
- No. CAS: 216699-07-9
- Fòrmula: C14H20N6O5S
- Peso molecular:384.41
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Abacavir monosulfate
More- Cancer Res. 2026 Jul 15;86(14):3588-3603. [Abstract]
- Adv Sci (Weinh). 2025 Jul;12(28):e2503579. [Abstract]
- Aging Cell. 2026 Jan 20;25(2):e70352.
- Int J Antimicrob Agents. 2019 Dec;54(6):814-819. [Abstract]
- ASN Neuro. 2026;18(1):2647877. [Abstract]
- Antiviral Res. 2023 Aug:216:105674. [Abstract]
- Virology. 2026 Jun 4:623:110991. [Abstract]
- bioRxiv. 2026 Jul 18.
- J Mol Liq. 2018 Feb;251:345-357.
Actividad biológica
Descripciòn
In Vitro
Abacavir (15 and 150 μM, 0-120 h) monosulfate inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines[1].
Abacavir (15 and 150 μM, 18 h) monosulfate significantly reduces cell migration and inhibits cell invasion[1].
Abacavir monsulfate induces fat apoptosis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3, LNCaP and WI-38
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Concentration:15 and 150 μM
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Incubation Time:0, 24, 48, 72 and 96 h
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Result:Showed a dose-dependent growth inhibition on PC3 and LNCaP.
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Cell Line:PC3 and LNCaP
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Concentration:150 μM
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Incubation Time:0, 18, 24, 48, 72, 96 and 120 h
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Result:Caused a very high accumulation of cells in S phase in PC3 and LNCaP cells, and G2/M phase increment was observed in PC3 cells.
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Cell Line:PC3 and LNCaP
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Concentration:15 and 150 μM
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Incubation Time:18 h
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Result:Significantly reduced cell migration.
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Cell Line:PC3 and LNCaP
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Concentration:15 and 150 μM
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Incubation Time:18 h
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Result:Significantly inhibited cell invision.
In Vivo
Abacavir (50 mg/kg/d; i.p.; 14 days) monosulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)[2]
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Dosage:2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg
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Administration:Intrascrotal or oral administration for 4 h
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Result:Dose-dependently promoted thrombus formation.
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Animal Model:NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma[3]
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Dosage:50 mg/kg/d with 0.1 mg/kg/d Decitabine
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Administration:Intraperitoneal injection, daily for 14 days
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Result:Inhibited tumor growth and enhanced mouse survival.
Chemical Information
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No. CAS 216699-07-9
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Appearance Powder
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Peso molecular 384.41
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Fòrmula C14H20N6O5S
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Color white
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SMILES
NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](CO)C4)C3=N1.O=S(O)(O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (9)
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Journal Impact Factor
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Most Recent
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Cancer Res
Targeting DOT1L Reactivates HERV-K to Drive Cell-Autonomous and Paracrine Senescence in Adenocarcinoma of the Esophagogastric Junction. [Abstract]2026 Jul 15;86(14):3588-3603. PMID: 42084229 -
Adv Sci (Weinh)
Neuronal FGF13 Inhibits Mitochondria-Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease. [Abstract]2025 Jul;12(28):e2503579. PMID: 40344619 -
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Int J Antimicrob Agents
2019 Dec;54(6):814-819. PMID: 31479744 -
ASN Neuro
Exposure to Frontline Antiretroviral Dolutegravir Disrupts Oligodendrocyte Development Across Differentiation Stages. [Abstract]2026;18(1):2647877. PMID: 41904696 -
Antiviral Res
Seasonal coronavirus infections trigger NLRP3 inflammasome activation in macrophages but is therapeutically targetable. [Abstract]2023 Aug:216:105674. PMID: 37459896 -
Virology
Generation and evaluation of an EcoHIV mouse model to study HIV-1 integration and expression. [Abstract]2026 Jun 4:623:110991. PMID: 42320113 -
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Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5(12):e14221. [Content Brief]
[2]. Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218(2):228-233. [Content Brief]
[3]. Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23(7):3815. [Content Brief]
[4]. McComsey GA, et al. Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS. 2005 Jan 3;19(1):15-23. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Abacavir monosulfate Related Classifications
HY-17423B Related Classifications
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