Acarbose sulfate
Based on 15 publication(s) in Google Scholar
Acarbose (BAY g 5421) sulfate, antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose sulfate can potentiate the hypoglycemic effects of sulfonylureas or insulin.
For research use only. We do not sell to patients.
- CAS No.: 1221158-13-9
- Formula: C25H45NO22S
- Molecular Weight:743.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Acarbose sulfate
More- Cancer Res. 2026 Jul 17.
- Research (Wash D C). 2026 Feb 25:9:1161. [Abstract]
- J Neuroinflammation. 2026 May 2;23(1):206. [Abstract]
- Phytomedicine. 2026 Oct:160:158619.
- Antioxidants (Basel). 2026 May 29;15(6):688. [Abstract]
- Aging Cell. 2026 Jan 20;25(2):e70352.
- Nat Prod Bioprospect. 2023 Jan 9;13(1):2. [Abstract]
- Int J Mol Sci. 2025 Feb 6;26(3):1381. [Abstract]
- Front Pharmacol. 2025 Apr 30:16:1573032. [Abstract]
- Pest Manag Sci. 2021 Nov;77(11):5294-5303. [Abstract]
- J Infect Dis. 2025 Nov 12:jiaf567. [Abstract]
- Phytochemistry. 2022 Apr:196:113083. [Abstract]
- Biochem Syst Ecol. 2025 Oct.
- Bratisl Lek Listy. 2026 Jun 17.
- SSRN. 2025 Jul 25.
Customer Validation & Images
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Bio/Physico-chemical Assay
Biological Activity
Description
In Vitro
Acarbose (1, 2, and 3 μM) dose- and time-dependently inhibits TNF-α-induced VSMC proliferation and migration. Acarbose (1, 2, and 3 μM) dose-dependently decreases β-galactosidase, Ras expression and increased p-AMPK expression in TNF-α pre-treated A7r5 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1221158-13-9
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Molecular Weight 743.68
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Formula C25H45NO22S
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SMILES
O[C@@H]1C(CO)=C[C@H](N[C@H]2[C@H](O)[C@@H](O)[C@@H](O[C@@H]3[C@@H](CO)O[C@H](O[C@@H]4[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O)O[C@@H]2C)[C@H](O)[C@H]1O.O=S(O)(O)=O
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Synonyms
Bay-g 5421 sulfate
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Structure Classification
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Initial Source
?Actinoplanes sp. SE50/110
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (15)
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Journal Impact Factor
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Most Recent
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Research (Wash D C)
Repurposed Acarbose Targets Nidogen-1 to Remodel the Tumor Stroma and Suppress Portal Vein Tumor Thrombus in Hepatocellular Carcinoma. [Abstract]2026 Feb 25:9:1161. PMID: 41756725 -
J Neuroinflammation
Acarbose modulates microglial Pkm2 acetylation to reshape immunometabolism and preserve retinal neurons after ischemia-reperfusion. [Abstract]2026 May 2;23(1):206. PMID: 42069589 -
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Antioxidants (Basel)
Bioactive Extracts and Constituents from Taraxacum mongolicum: Antioxidant, Anti-Inflammatory, Enzyme-Inhibitory, and Molecular Docking Studies. [Abstract]2026 May 29;15(6):688. PMID: 42351994 -
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Nat Prod Bioprospect
2023 Jan 9;13(1):2. PMID: 36617588 -
Int J Mol Sci
Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation. [Abstract]2025 Feb 6;26(3):1381. PMID: 39941149 -
Front Pharmacol
Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells. [Abstract]2025 Apr 30:16:1573032. PMID: 40371351 -
Pest Manag Sci
Suppression of Bta11975, an α-glucosidase, by RNA interference reduces transmission of tomato chlorosis virus by Bemisia tabaci. [Abstract]2021 Nov;77(11):5294-5303. PMID: 34310017
Acarbose sulfate purchased from MedChemExpress. Usage Cited in: Pest Manag Sci. 2021 Nov;77(11):5294-5303. [Abstract]
Effects of Acarbose (500-2000 ng/μL) concentration on AGLU activity in Bemisia tabaci MED. Addition of 750 ng/μL of Acarbose to the nutrient solution caused about 50% inhibition of AGLU activity in B. tabaci MED.
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J Infect Dis
Ampicillin/Sulbactam in Combination with Ceftazidime/Avibactam against Metallo-β-Lactamase-Producing Carbapenem-Resistant Acinetobacter baumannii: A Genomics-Informed Mechanism-Based Model. [Abstract]2025 Nov 12:jiaf567. PMID: 41223187 -
Phytochemistry
2022 Apr:196:113083. PMID: 34999512 -
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Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Purity & Documentation
References
[1]. Hanefeld M, et al. Acarbose: oral anti-diabetes drug with additional cardiovascular benefits [published correction appears in Expert Rev Cardiovasc Ther. 2009 Mar;7(3):330]. Expert Rev Cardiovasc Ther. 2008;6(2):153-163. [Content Brief]
[2]. Yee HS, et al. A review of the safety and efficacy of acarbose in diabetes mellitus. Pharmacotherapy. 1996;16(5):792-805. [Content Brief]
[3]. Oki T, et al. Evaluation of alpha-glucosidase inhibition by using an immobilized assay system. Biol Pharm Bull. 2000;23(9):1084-1087. [Content Brief]
[4]. Zhang Q, et al. Acarbose Reduces Blood Glucose by Activating miR-10a-5p and miR-664 in Diabetic Rats. PLoS One. 2013 Nov 18;8(11):e79697. [Content Brief]
[5]. Chan KC, et al. Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. Sci Rep. 2016 Dec 7;6:3864 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Acarbose sulfate Related Classifications
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