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  3. Aleglitazar

Aleglitazar (Synonyms: R1439; RO0728804)

Cat. No.: HY-14728 Purity: 99.30%
Handling Instructions

Aleglitazar(R1439; RO-0728804) is a new dual PPAR-α/γ agonist with IC50 of 2.8 nM/4.6 nM.

For research use only. We do not sell to patients.

Aleglitazar Chemical Structure

Aleglitazar Chemical Structure

CAS No. : 475479-34-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 715 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Aleglitazar(R1439; RO-0728804) is a new dual PPAR-α/γ agonist with IC50 of 2.8 nM/4.6 nM. IC50 Value: 2.8 nM(PPAR-α); 4.6 nM(PPAR-γ) Target: PPARα/γ Aleglitazar (R1439) is a dual peroxisome proliferator-activated receptor (PPAR) agonist, with affinity to PPARα and PPARγ. Aleglitazar is being developed for the treatment of type II diabetes; It is currently in phase III clinical trials. In preliminary clinical studies, Aleglitazar has been demonstrated to improve hyperglycemia and dyslipidemia in patients with type 2 diabetes mellitus. Aleglitazar has beneficial effects on both lipid and glucose parameters and may have a therapeutic role in modifying cardiovascular risk factors and improving glycemic control in patients with T2DM. Aleglitazar combines the lipid benefits of fibrates and the insulin-sensitizing benefits of thiazolidinediones.

IC50 & Target[5]

PPARγ

19 nM (IC50)

PPARα

38 nM (IC50)

Clinical Trial
Molecular Weight

437.51

Formula

C₂₄H₂₃NO₅S

CAS No.

475479-34-6

SMILES

CC1=C(CCOC2=CC=C(C[[email protected]@H](C(O)=O)OC)C3=C2C=CS3)N=C(C4=CC=CC=C4)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (114.28 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2857 mL 11.4283 mL 22.8566 mL
5 mM 0.4571 mL 2.2857 mL 4.5713 mL
10 mM 0.2286 mL 1.1428 mL 2.2857 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.30%

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Keywords:

AleglitazarR1439RO0728804R 1439R-1439RO 0728804RO-0728804PPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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Product name:
Aleglitazar
Cat. No.:
HY-14728
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