S100 alpha Antibody (YA5695)

Art. -Nr.: HY-P86003: Data Sheet User Guide for Antibodies
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S100 alpha Antibody (YA5695) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to S100 alpha.

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Größe		Verfügbarkeit
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100 μL		Angebot einholen

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung
Verweise

Beschreibung

S100 alpha Antibody (YA5695) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to S100 alpha.

Host

Mouse

Clonality

Monoclonal

Molekulargewicht

Predicted band size: 11 kDa;

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P23297

Gene ID

6271 [NCBI]

Immunogen

Synthesized peptide derived from human S100A1 AA range: 1-50

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:500-5000

Reinheit	affinity chromatography.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446)

Subcellular Localization：Cytoplasm; Sarcoplasmic reticulum; Mitochondrion

Expression：
Tissue_specificity:It is abundant in the heart (PubMed: 12804600, PubMed: 1384693) . Small amounts have also been found in skeletal muscle and the brain (PubMed: 1384693) .

Subunit：Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain (PubMed:21296671). Also forms heterodimers with S100P (PubMed:15171681).

Synonyms

Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1;

Dokumentation

User Guide for Antibodies (1077 KB)

Verweise

[1]. /biology-dictionary/sw-620-cell.html [Content Brief]