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United States

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製品番号: HY-183060

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Antitumor agent-215

Antitumor agent-215 is an antitumor agent. Antitumor agent-215 occupies the binding pocket of thymidylate synthase and interacts with key catalytic residues. Antitumor agent-215 induces cancer cell apoptosis and cell cycle arrest, and inhibits cell proliferation. Antitumor agent-215 can be used in the research of breast cancer and colorectal cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₂H₁₈N₂O₂S
分子量:374.46

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antitumor agent-215 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Antitumor agent-215 (compound 5c) (48 h) potently inhibits the proliferation of MCF-7 breast cancer cells and SW480 colorectal cancer cells, with an IC₅₀ of 4.25 μM against the former and 14.30 μM against the latter^[1].
Antitumor agent-215 (3-12 μM; 48 h) induces apoptosis in MCF-7 breast cancer cells in a concentration-dependent manner^[1].
Antitumor agent-215 (3-12 μM; 72 h) disrupts DNA synthesis in MCF-7 breast cancer cells, causing dose-dependent cell cycle arrest that primarily occurs at the S phase^[1].
Antitumor agent-215 exhibits favorable predicted oral bioavailability and pharmacokinetic properties, but carries predicted risks of mutagenicity, carcinogenicity, and moderate hERG inhibition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

human breast cancer MCF-7 cells
Concentration:

3, 6, 12 μM
Incubation Time:

48 h
Result:

Induced a concentration-dependent increase in Annexin V-positive cells, rising from 2.86% in untreated controls to 6.30%, 52.10%, and 58.0% at 3 μM, 6 μM, and 12 μM, respectively.

Cell Cycle Analysis^[1]

Cell Line:

human breast cancer MCF-7 cells
Concentration:

3, 6, 12 μM
Incubation Time:

72 h
Result:

Caused a progressive dose-dependent decrease in the G0/G1 cell population and a corresponding increase in cells arrested at the S phase.
Showed minor fluctuations in G2/M phase populations.

化学情報

分子量 374.46
分子式 C₂₂H₁₈N₂O₂S
SMILES

O=C1N(C2=CC=CC=C2)C(SCC3=CC=C(C)C=C3)=NC4=C1C=C(O)C=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Mansouri M M, et al. Design and synthesis of novel substituted quinazoline-4-one derivatives along with computational and biological evaluation. Heliyon, 2026, 12(7).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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