2. Antitumor agent-215

Antitumor agent-215 is an antitumor agent. Antitumor agent-215 occupies the binding pocket of thymidylate synthase and interacts with key catalytic residues. Antitumor agent-215 induces cancer cell apoptosis and cell cycle arrest, and inhibits cell proliferation. Antitumor agent-215 can be used in the research of breast cancer and colorectal cancer.

For research use only. We do not sell to patients.

Antitumor agent-215

Antitumor agent-215 Chemical Structure

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Antitumor agent-215 Related Antibodies

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Description

Antitumor agent-215 is an antitumor agent. Antitumor agent-215 occupies the binding pocket of thymidylate synthase and interacts with key catalytic residues. Antitumor agent-215 induces cancer cell apoptosis and cell cycle arrest, and inhibits cell proliferation. Antitumor agent-215 can be used in the research of breast cancer and colorectal cancer[1].

In Vitro

Antitumor agent-215 (compound 5c) (48 h) potently inhibits the proliferation of MCF-7 breast cancer cells and SW480 colorectal cancer cells, with an IC50 of 4.25 μM against the former and 14.30 μM against the latter[1].
Antitumor agent-215 (3-12 μM; 48 h) induces apoptosis in MCF-7 breast cancer cells in a concentration-dependent manner[1].
Antitumor agent-215 (3-12 μM; 72 h) disrupts DNA synthesis in MCF-7 breast cancer cells, causing dose-dependent cell cycle arrest that primarily occurs at the S phase[1].
Antitumor agent-215 exhibits favorable predicted oral bioavailability and pharmacokinetic properties, but carries predicted risks of mutagenicity, carcinogenicity, and moderate hERG inhibition[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-215 Related Antibodies

Apoptosis Analysis[1]

Cell Line: human breast cancer MCF-7 cells
Concentration: 3, 6, 12 μM
Incubation Time: 48 h
Result: Induced a concentration-dependent increase in Annexin V-positive cells, rising from 2.86% in untreated controls to 6.30%, 52.10%, and 58.0% at 3 μM, 6 μM, and 12 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: human breast cancer MCF-7 cells
Concentration: 3, 6, 12 μM
Incubation Time: 72 h
Result: Caused a progressive dose-dependent decrease in the G0/G1 cell population and a corresponding increase in cells arrested at the S phase.
Showed minor fluctuations in G2/M phase populations.
Molecular Weight

374.46

Formula

C22H18N2O2S
SMILES

O=C1N(C2=CC=CC=C2)C(SCC3=CC=C(C)C=C3)=NC4=C1C=C(O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-215 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-215Antitumor agent215Antitumor agent 215SW480 colorectal cancer cellsbreast cancercolorectal cancer cellsbreast cancer cellscell cycle arrestthymidylate synthaseMCF-7 breast cancer cellscolorectal cancerapoptosisDNA synthesisInhibitorinhibitorinhibit

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