Asteltoxin

Cat. No.: HY-119665: FAQs
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Asteltoxin is an inhibitor for extracellular vesicles (EV), which exhibits inhibitory effects towards mitochondrial ATP synthase and mTORC1 activation.

For research use only. We do not sell to patients.

Asteltoxin Chemical Structure

CAS No. : 79663-49-3

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Biological Activity
Purity & Documentation
References
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Description

Asteltoxin is an inhibitor for extracellular vesicles (EV), which exhibits inhibitory effects towards mitochondrial ATP synthase and mTORC1 activation^[1].

In Vitro

Asteltoxin (1-100 μg/ml) inhibits the production of CD63-positive EV with IC₅₀ of 2.1 μg/ml and exhibits no significant cytotoxicity in HT29 cells^[1].
Asteltoxin (1-10 μg/ml) activates AMPK pathways and inhibits mTORC1 pathways by inducing a decrease in ATP level, therefore activates lysosome function and inhibits the EV secretion of cancer cells PC-3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	HT-29
Concentration:	1-100 μg/ml
Incubation Time:	24 h
Result:	Exhibited cytotoxicity with an IC₅₀ over 100 μg/ml.

Cell Proliferation Assay^[1]

Cell Line:	PC-3
Concentration:	1-10 μg/ml
Incubation Time:	3 days
Result:	Revealed no effect on anchorage-dependent growth of PC-3.

Western Blot Analysis^[1]

Cell Line:	PC-3
Concentration:	1-10 μg/ml
Incubation Time:	24 h
Result:	Increased levels of pAMPK Decreased levels of pS6K and p4E-BP1.

Molecular Weight

418.48

Formula

C₂₃H₃₀O₇

CAS No.

79663-49-3

SMILES

O=C1C=C(C(C)=C(O1)/C=C/C=C/C=C/[C@@H]2[C@@H]([C@]3(C)[C@@](O)([C@H](O[C@@]3(O2)[H])CC)C)O)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mitani F,et al., Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function. Sci Rep. 2022 Apr 23;12(1):6674. [Content Brief]

Asteltoxin Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asteltoxin79663-49-3AMPKmTORAMP-activated protein kinaseMammalian target of RapamycinHT29 colon cancer cellPC-3Inhibitorinhibitorinhibit

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