Aldo-keto reductase family 1 member B10

Definition

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no reductase activity towards glucose.

References:

[1]. D Cao, et al. Identification and characterization of a novel human aldose reductase-like gene. J Biol Chem. 1998 May 8;273(19):11429-35. [Content Brief]

[2]. Hans-Jörg Martin, et al. Role of human aldo-keto-reductase AKR1B10 in the protection against toxic aldehydes. Chem Biol Interact. 2009 Mar 16;178(1-3):145-50. [Content Brief]

[3]. Oriol Gallego, et al. Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20764-9. [Content Brief]

[4]. Bernat Crosas, et al. Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism. Biochem J. 2003 Aug 1;373(Pt 3):973-9. [Content Brief]

[5]. Linlin Zhong, et al. Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels. Biochem Biophys Res Commun. 2009 Sep 18;387(2):245-50. [Content Brief]

生物医学辞典

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