Aplasia of lacrimal and salivary glands

Definition:

Aplasia of lacrimal and salivary glands (ALSG) is a rare autosomal dominant condition characterized by insufficient development of the lacrimal and salivary systems. Patients with ALSG suffer from irritable eyes and dryness of the mouth. Mutations in FGF10 were recently described in ALSG.

References:

[1]. Kathrin Scheckenbach, et al. An intronic alteration of the fibroblast growth factor 10 gene causing ALSG-(aplasia of lacrimal and salivary glands) syndrome. BMC Med Genet. 2008 Dec 22;9:114. [Content Brief]

[2]. Miriam Entesarian, et al. FGF10 missense mutations in aplasia of lacrimal and salivary glands (ALSG). Eur J Hum Genet. 2007 Mar;15(3):379-82. [Content Brief]

[3]. Miriam Entesarian, et al. Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands. Nat Genet. 2005 Feb;37(2):125-7. [Content Brief]

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