Biorientation of chromosomes in cell division protein 1-like 1

Definition:

Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation.

References:

[1]. Martin R Higgs, et al. BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks. Mol Cell. 2015 Aug 6;59(3):462-77. [Content Brief]

[2]. Martin R Higgs, et al. Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2. Mol Cell. 2018 Jul 5;71(1):25-41.e6. [Content Brief]

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