Breast cancer anti-estrogen resistance protein 1

Definition:

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration and cell branching. Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity).

References:

[1]. Katarzyna Modzelewska, et al. Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. J Biol Chem. 2006 Dec 8;281(49):37527-35. [Content Brief]

[2]. Akira Sakakibara, et al. Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. J Cell Sci. 2002 Dec 15;115(Pt 24):4915-24. [Content Brief]

[3]. Yama A Abassi, et al. p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration. J Biol Chem. 2003 Sep 12;278(37):35636-43. [Content Brief]

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