C-C motif chemokine 26

Definition:

Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils. Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis.

References:

[1]. J Ye, et al. NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3. Biochemistry. 2001 Jul 3;40(26):7820-31. [Content Brief]

[2]. Takashi Nakayama, et al. Eotaxin-3/CC chemokine ligand 26 is a functional ligand for CX3CR1. J Immunol. 2010 Dec 1;185(11):6472-9. [Content Brief]

[3]. M Kitaura, et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J Biol Chem. 1999 Sep 24;274(39):27975-80. [Content Brief]

[4]. A Shinkai, et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J Immunol. 1999 Aug 1;163(3):1602-10. [Content Brief]

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