C-type lectin domain family 4 member G

Definition:

Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.; (Microbial infection) Acts as a receptor for Japanese encephalitis virus.; (Microbial infection) Acts as a receptor for Ebolavirus.; (Microbial infection) Acts as a receptor for SARS-CoV.; (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein.

References:

[1]. Thomas Gramberg, et al. LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus. Virology. 2005 Sep 30;340(2):224-36. [Content Brief]

[2]. Masayuki Shimojima, et al. Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry. J Virol. 2012 Feb;86(4):2067-78. [Content Brief]

[3]. Masayuki Shimojima, et al. Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin. Arch Virol. 2014 Aug;159(8):2023-31. [Content Brief]

[4]. Masayuki Shimojima, et al. Cell surface molecules involved in infection mediated by lymphocytic choriomeningitis virus glycoprotein. J Vet Med Sci. 2012 Oct;74(10):1363-6. [Content Brief]

[5]. Wanli Liu, et al. Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node. J Biol Chem. 2004 Apr 30;279(18):18748-58. [Content Brief]

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