calcium/calmodulin-dependent protein kinase kinase 2, β (CAMKK2/CaMKKβ)

Definition:

Calcium/calmodulin-dependent protein kinase kinase 2, β (CAMKK2/CaMKKβ) is a serine/threonine-directed kinase that is activated following increases in intracellular Ca²⁺.CaMKKβ activates Ca²⁺/calmodulin-dependent protein kinase I, Ca²⁺/calmodulin-dependent protein kinase IV, and the AMP-dependent protein kinase in a number of physiological pathways, including learning and memory formation, neuronal differentiation, and regulation of energy balance.

References:

[1]. Green et al. Ca2+/Calmodulin-dependent protein kinase kinase beta is regulated by multisite phosphorylation. J Biol Chem. 2011 Aug 12;286(32):28066-79. [Content Brief]

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